Wang Tao, Yang Guang-You, Yan Hui-Juan, Wang Shuai, Bian Yao, Chen An-Chun, Bi Feng-Jun
Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China.
Vet Parasitol. 2008 May 6;153(1-2):121-5. doi: 10.1016/j.vetpar.2008.01.012. Epub 2008 Jan 17.
An experiment was conducted to evaluate the efficacy of ivermectin and mebendazole compared with selamectin against gastrointestinal nematodes in rhesus macaques. A total of 60 rhesus macaques (Macaca mulatta), which were all infected with gastrointestinal nematodes, were randomly assigned to three treatment groups (selamectin, ivermectin and mebendazole) and one control group. Fecal samples for determining nematode egg counts were collected pre- and post-treatment. All treatments resulted in decrease in the number of eggs per gram (EPG) in the post-treatment sample compared with the pre-treatment sample. Reductions of mean egg counts from day -3 levels were 99.4% for selamectin, 99.2% for ivermectin and 99.4% for mebendazole on trial day 11, respectively. However, no significant difference was found among treatment groups. According to the data demonstrating a similar efficacy in selamectin-, ivermectin- and mebendazole-treated rhesus macaques, it was effective and convenient to apply either selamectin and ivermectin or mebendazole in rotation on the local conditions.
进行了一项实验，以评估伊维菌素和甲苯咪唑与塞拉菌素相比对恒河猴胃肠道线虫的疗效。总共60只均感染胃肠道线虫的恒河猴（猕猴）被随机分配到三个治疗组（塞拉菌素、伊维菌素和甲苯咪唑）和一个对照组。在治疗前和治疗后收集用于测定线虫虫卵计数的粪便样本。与治疗前样本相比，所有治疗均导致治疗后样本中每克虫卵数（EPG）减少。在试验第11天，塞拉菌素、伊维菌素和甲苯咪唑从第-3天水平起的平均虫卵计数减少率分别为99.4%、99.2%和99.4%。然而，各治疗组之间未发现显著差异。根据表明塞拉菌素、伊维菌素和甲苯咪唑治疗的恒河猴疗效相似的数据，根据当地情况轮流使用塞拉菌素和伊维菌素或甲苯咪唑既有效又方便。
