van Herten Marieke, Pasman Jaco, van Leeuwen Theo H, Been Pieter H, van der Leij Aryan, Zwarts Frans, Maassen Ben
Paediatric Neurology Centre, Department of Clinical Neurophysiology, Radboud University Nijmegen Medical Centre, The Netherlands.
Brain Res. 2008 Mar 27;1201:100-5. doi: 10.1016/j.brainres.2008.01.060. Epub 2008 Feb 5.
To determine the auditory event-related potential (AERP) correlates of phoneme perception in 17-month-old children at risk of dyslexia and controls, AERPs were elicited by standard (/bAk/) and deviant (/dAk/) word stimuli presented in an oddball paradigm. The at-risk children tended to show delayed P1 and P2 peaks for standard stimuli. Hemispheric group differences were observed for N2 amplitude and P1 latency, suggesting atypical processing of spoken words in at-risk children. Larger P2 and to a lesser extent P1 amplitudes following deviant words occurred in the control but not in the at-risk group, this may signal poorer phoneme discrimination in at-risk children. The present AERP results offer clues to where to look for a marker to identify children at high risk of reading and writing problems at an early age to facilitate early intervention.
为了确定有诵读困难风险的17个月大儿童和对照组儿童音素感知的听觉事件相关电位（AERP）相关性，通过以奇偶数范式呈现的标准（/bAk/）和偏差（/dAk/）单词刺激诱发AERP。有风险的儿童对标准刺激往往表现出P1和P2峰值延迟。在N2振幅和P1潜伏期观察到半球组差异，表明有风险的儿童对口语单词的处理存在非典型情况。对照组在偏差单词后出现较大的P2，在较小程度上出现较大的P1振幅，而有风险组则未出现，这可能表明有风险的儿童音素辨别能力较差。目前的AERP结果为寻找一种标记物提供了线索，以便在早期识别有读写问题高风险的儿童，从而促进早期干预。
