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肾移植术后肺毛霉病:一例报告及文献复习

Pulmonary mucormycosis after renal transplantation: A case report and a literature review.

作者信息

Abu Asabeh Ekhlass, Zeer Zahraa M M, Dukmak Osama N, Eid Al Mohtasib Mohammad, Abu Asbeh Yousef

机构信息

Faculty of Medicine, Al-Quds University, Palestine.

Thoracic Surgery Department, Al-Ahli Hospital, Palestine.

出版信息

Ann Med Surg (Lond). 2022 Jun 1;78:103889. doi: 10.1016/j.amsu.2022.103889. eCollection 2022 Jun.

Abstract

Mucormycosis is a rare fungal infection mostly encountered in immunosuppressed patients. Other major risk factors are diabetes mellitus, solid organ transplant and chronic use of glucocorticoids. Early diagnosis should be obtained as soon as possible due to the infection's aggressive behavior and high probability of dissemination. Here we present a case of pulmonary mucormycosis in a non-diabetic patient, known to have systemic lupus erythematous and had a renal transplant recently presented with shortness of breath and was treated with antibiotic as a case of chest infection with minimal improvement. Then, after full investigations, he seemed to have mucormycosis which was successfully treated with combined liposomal amphotericin B and resection of the infectious lesion.

摘要

毛霉病是一种罕见的真菌感染,多见于免疫抑制患者。其他主要危险因素包括糖尿病、实体器官移植和长期使用糖皮质激素。由于该感染具有侵袭性且极易播散,应尽快进行早期诊断。在此,我们报告一例非糖尿病患者的肺毛霉病病例,该患者患有系统性红斑狼疮且近期接受了肾移植,因出现呼吸急促而就诊,最初被当作胸部感染用抗生素治疗,但症状改善甚微。经过全面检查后,发现他患的是毛霉病,通过联合使用脂质体两性霉素B并切除感染病灶,最终成功治愈。

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