Reddy M M, Weissman A M, Mazza D S, Meriney D K, Johns M, Carrabis S, Grieco M H
R.A. Cooke Institute of Allergy, St. Luke's/Roosevelt Hospital, New York, New York.
Ann Allergy. 1992 Aug;69(2):131-4.
Circulating IgE protein levels, leukocyte counts, lymphocyte subsets, IL-4, and soluble CD23 levels were quantitated in 43 atopic and 19 nonatopic subjects. Mean values of IgE protein levels, total eosinophil counts, CD20+CD23+ cells (B cells with low-affinity IgE receptor), IL-4 and sCD23 levels were elevated in atopic patients compared with nonatopic controls. The results suggest that sCD23, IL-4, and CD20+CD23+ lymphocytes may play a role in the increased production of IgE in atopic subjects in a manner similar to that observed by other investigators in prior in vitro studies.
对43名特应性受试者和19名非特应性受试者的循环IgE蛋白水平、白细胞计数、淋巴细胞亚群、白细胞介素-4（IL-4）和可溶性CD23水平进行了定量分析。与非特应性对照相比，特应性患者的IgE蛋白水平、嗜酸性粒细胞总数、CD20+CD23+细胞（具有低亲和力IgE受体的B细胞）、IL-4和可溶性CD23（sCD23）水平的平均值升高。结果表明，sCD23、IL-4和CD20+CD23+淋巴细胞可能以与其他研究者先前体外研究中观察到的方式类似的方式，在特应性受试者IgE产生增加中发挥作用。
