Boecker Henning, Sprenger Till, Spilker Mary E, Henriksen Gjermund, Koppenhoefer Marcus, Wagner Klaus J, Valet Michael, Berthele Achim, Tolle Thomas R
Nuklearmedizinische Klinik, Klinikum rechts der Isar, Technische Universität München, 81675 München, Germany.
Cereb Cortex. 2008 Nov;18(11):2523-31. doi: 10.1093/cercor/bhn013. Epub 2008 Feb 21.
The runner's high describes a euphoric state resulting from long-distance running. The cerebral neurochemical correlates of exercise-induced mood changes have been barely investigated so far. We aimed to unravel the opioidergic mechanisms of the runner's high in the human brain and to identify the relationship to perceived euphoria. We performed a positron emission tomography "ligand activation" study with the nonselective opioidergic ligand 6-O-(2-[(18)F]fluoroethyl)-6-O-desmethyldiprenorphine ([(18)F]FDPN). Ten athletes were scanned at 2 separate occasions in random order, at rest and after 2 h of endurance running (21.5 +/- 4.7 km). Binding kinetics of [(18)F]FDPN were quantified by basis pursuit denoising (DEPICT software). Statistical parametric mapping (SPM2) was used for voxelwise analyses to determine relative changes in ligand binding after running and correlations of opioid binding with euphoria ratings. Reductions in opioid receptor availability were identified preferentially in prefrontal and limbic/paralimbic brain structures. The level of euphoria was significantly increased after running and was inversely correlated with opioid binding in prefrontal/orbitofrontal cortices, the anterior cingulate cortex, bilateral insula, parainsular cortex, and temporoparietal regions. These findings support the "opioid theory" of the runner's high and suggest region-specific effects in frontolimbic brain areas that are involved in the processing of affective states and mood.
跑步者高潮描述的是一种因长跑产生的欣快状态。迄今为止，运动诱发情绪变化的大脑神经化学关联几乎未被研究过。我们旨在揭示人类大脑中跑步者高潮的阿片类机制，并确定其与感知到的欣快感之间的关系。我们使用非选择性阿片类配体6-O-(2-[(18)F]氟乙基)-6-O-去甲基二丙诺啡([(18)F]FDPN)进行了一项正电子发射断层扫描“配体激活”研究。10名运动员以随机顺序在两个不同场合接受扫描，一次是在休息时，另一次是在耐力跑2小时（21.5±4.7公里）后。[(18)F]FDPN的结合动力学通过基追踪去噪（DEPICT软件）进行量化。使用统计参数映射（SPM2）进行体素分析，以确定跑步后配体结合的相对变化以及阿片类结合与欣快感评分之间的相关性。阿片受体可用性的降低优先在额叶前部和边缘/边缘旁脑结构中被发现。跑步后欣快感水平显著升高，并且与额叶/眶额皮质、前扣带回皮质、双侧脑岛、脑岛旁皮质和颞顶叶区域的阿片类结合呈负相关。这些发现支持了跑步者高潮的“阿片理论”，并表明在前额叶边缘脑区存在区域特异性效应，这些脑区参与情感状态和情绪的处理。
