脊髓运动神经元Ia突触处电荷转移的统计波动。
Statistical fluctuations in charge transfer at Ia synapses on spinal motoneurones.
作者信息
Edwards F R, Redman S J, Walmsley B
出版信息
J Physiol. 1976 Aug;259(3):665-88. doi: 10.1113/jphysiol.1976.sp011488.
Abstract
- Net inward charge is calculated for unitary Ia e.p.s.p.s. evoked in spinal motoneurones. Fluctuations in this charge are used to describe the fluctuations in transmission at the Ia synapse. 2. The statistical details of variation in transmission at Ia synapses are largely obscured by noise, arising from spontaneous activity and recording apparatus. 3. A computational procedure is described, which utilized the measured statistical properties of the recording noise, and the measured charge histogram of the evoked e.p.s.p. (with noise) to calculate the variations in charge due to the e.p.s.p. alone. 4. The fluctuation in charge transmission at Ia synapses are, in general, non-quantal. Nor are they described by binomial or Poisson statistics. 5. It is suggested that the basic mode of transmission at a single terminal is all-or-none. The fluctuations result from the combined effect of failures at several terminals arising from a single afferent fibre. This hypothesis is supported by further analysis of these results in a subsequent paper (Edwards, Redman & Walmysley, 1976a).
摘要
- 计算脊髓运动神经元中诱发的单突触Ia兴奋性突触后电位（e.p.s.p.s）的内向净电荷。该电荷的波动用于描述Ia突触传递的波动。2. Ia突触传递变化的统计细节在很大程度上被自发活动和记录设备产生的噪声所掩盖。3. 描述了一种计算程序，该程序利用记录噪声的测量统计特性以及诱发的兴奋性突触后电位（带噪声）的测量电荷直方图来计算仅由兴奋性突触后电位引起的电荷变化。4. 一般来说，Ia突触处电荷传递的波动是非量子化的。二项式或泊松统计也无法描述它们。5. 有人提出，单个终末的基本传递模式是全或无的。这些波动是由单个传入纤维在多个终末处的失败的综合效应导致的。后续论文（爱德华兹、雷德曼和瓦尔姆斯利，1976a）对这些结果的进一步分析支持了这一假设。
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本文引用的文献
1
An analysis of the end-plate potential recorded with an intracellular electrode.用细胞内电极记录的终板电位分析。
J Physiol. 1951 Nov 28;115(3):320-70. doi: 10.1113/jphysiol.1951.sp004675.
2
QUANTAL COMPONENTS OF EXCITATORY SYNAPTIC POTENTIALS IN SPINAL MOTONEURONES.脊髓运动神经元兴奋性突触电位的量子成分
J Physiol. 1964 Dec;175(1):81-99. doi: 10.1113/jphysiol.1964.sp007504.
3
QUANTAL COMPONENTS OF THE SYNAPTIC POTENTIAL IN THE CILIARY GANGLION OF THE CHICK.鸡睫状神经节突触电位的量子成分
J Physiol. 1964 Dec;175(1):1-16. doi: 10.1113/jphysiol.1964.sp007499.
4
MECHANSIM OF FACILITATION AND DEPRESSION OF THE EXCITATORY SYNAPTIC POTENTIAL IN SPINAL MOTONEURONES.脊髓运动神经元兴奋性突触电位易化与抑制的机制
J Physiol. 1964 Dec;175(1):100-12. doi: 10.1113/jphysiol.1964.sp007505.
5
Stimulation of spinal motoneurones with intracellular electrodes.用细胞内电极刺激脊髓运动神经元。
J Physiol. 1956 Nov 28;134(2):451-70. doi: 10.1113/jphysiol.1956.sp005657.
6
An investigation of spontaneous activity at the neuromuscular junction of the rat.大鼠神经肌肉接头处自发活动的研究。
J Physiol. 1956 Jun 28;132(3):650-66. doi: 10.1113/jphysiol.1956.sp005555.
7
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J Physiol. 1969 Apr;201(2):479-93. doi: 10.1113/jphysiol.1969.sp008768.
8
Time constants and electrotonic length of membrane cylinders and neurons.膜圆柱体和神经元的时间常数与电紧张长度。
Biophys J. 1969 Dec;9(12):1483-508. doi: 10.1016/S0006-3495(69)86467-2.
9
The time course of minimal excitory post-synaptic potentials evoked in spinal motoneurones by group Ia afferent fibres.由Ia类传入纤维在脊髓运动神经元中诱发的最小兴奋性突触后电位的时间进程。
J Physiol. 1971 Jun;215(2):353-80. doi: 10.1113/jphysiol.1971.sp009474.
10
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