Amiel M L, Testart J, Benveniste J
Institut National de la Santé et de la Recherche Médicale (INSERM), Clamart, France.
Fertil Steril. 1991 Jul;56(1):62-5. doi: 10.1016/s0015-0282(16)54417-3.
Platelet-activating factor-acether (PAF-acether) presence was investigated in 27 human follicular fluids (FFs).
Aggregation of washed rabbit platelets was used to measure PAF-acether. Data were compared using Student's t-test.
Follicular fluids came from the in vitro fertilization program at Antoine Béclère Hospital, and PAF-acether was assayed at Institut National de la Santé et de la Recherche Médicale, Unités 187 and 200, Clamart, France.
PATIENTS, PARTICIPANTS: The study concerned five infertile women 29 to 39 years of age.
Ovaries were stimulated with human menopausal gonadotropin under gonadotropin-releasing hormone agonist (GnRH-a) action.
The height of platelet aggregation was compared between FFs and synthetic PAF-acether.
Mean FF concentration of PAF-acether was 1,367 to 3,467 pg/mL among women. Values were higher for patients in a long than in a short GnRH-a protocol (P less than 0.05). However, PAF-acether concentration was not related to fertilization rate.
Platelet-activating factor-acether is possibly involved in oocyte release from the follicle, a process occulted by follicular puncture.
研究27份人卵泡液（FF）中血小板活化因子-乙醚（PAF-乙醚）的存在情况。
使用洗涤过的兔血小板聚集来测量PAF-乙醚。数据采用学生t检验进行比较。
卵泡液来自安托万·贝克莱尔医院的体外受精项目，PAF-乙醚在法国克拉马尔的国家卫生与医学研究所在187和200单位进行检测。
患者、参与者：该研究涉及5名年龄在29至39岁的不孕女性。
在促性腺激素释放激素激动剂（GnRH-a）作用下，用人绝经期促性腺激素刺激卵巢。
比较卵泡液和合成PAF-乙醚之间的血小板聚集高度。
女性卵泡液中PAF-乙醚的平均浓度为1367至3467 pg/mL。长期使用GnRH-a方案的患者的值高于短期使用GnRH-a方案的患者（P<0.05）。然而，PAF-乙醚浓度与受精率无关。
血小板活化因子-乙醚可能参与卵泡中卵母细胞的释放，这一过程被卵泡穿刺所掩盖。
