对于经刺激的体外受精周期反复失败的女性来说，自然体外受精周期可能是可取的。
Natural IVF cycles may be desirable for women with repeated failures by stimulated IVF cycles.
作者信息
Matsuura Toshiki, Takehara Yuji, Kaijima Hirotsune, Teramoto Shokichi, Kato Osamu
机构信息
Kato Ladies Clinic, 7-20-3, Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
出版信息
J Assist Reprod Genet. 2008 Apr;25(4):163-7. doi: 10.1007/s10815-008-9204-7.
PURPOSE
Although many reports support stimulated in vitro fertilization, several patients do not respond to it well. Furthermore, stimulated treatment could be associated with reduced ovarian response. We describe three successful cases involving patients of advanced age from whom dominant follicles were retrieved during the natural cycle.
MATERIALS AND METHODS
All patients had failed to bear children through stimulated in vitro fertilization. In case 1, a follicle was retrieved after a gonadotropin-releasing hormone agonist was used to induce luteinizing hormone surge. In cases 2 and 3, pregnancy was achieved via completely natural cycles.
RESULTS
One embryo was transferred every 16 cycles. Ongoing pregnancy--defined as pregnancy progressing beyond gestation week 9--was established in three cycles. The patients successfully delivered and had uneventful neonatal courses.
CONCLUSION
Mature oocyte retrieval followed by natural rather than stimulated in vitro fertilization might be a potential treatment for patients of advanced age when stimulated in vitro fertilization has been repeatedly unsuccessful.
目的
尽管许多报告支持体外受精促排卵治疗，但仍有部分患者对此反应不佳。此外，促排卵治疗可能会导致卵巢反应降低。我们描述了三例成功案例，这些高龄患者在自然周期中获得了优势卵泡。
材料与方法
所有患者通过体外受精促排卵治疗均未能受孕。病例1中，使用促性腺激素释放激素激动剂诱导黄体生成素峰后获取了一个卵泡。病例2和病例3则通过完全自然周期成功受孕。
结果
每16个周期移植一枚胚胎。三个周期均实现了持续妊娠（定义为妊娠进展至9周以上）。患者顺利分娩，新生儿过程平稳。
结论
当体外受精促排卵反复失败时，对于高龄患者，自然周期获取成熟卵母细胞后进行体外受精可能是一种潜在的治疗方法。
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