Palermo V, Falcone C, Mazzoni C
Department of Cell and Developmental Biology, Pasteur Institute-Cenci Bolognetti Foundation, University of Rome La Sapienza, 5 00185 Rome, Italy.
Folia Microbiol (Praha). 2007;52(5):479-83. doi: 10.1007/BF02932107.
Cell viability during chronological aging and after apoptotic stimuli in some yeast mutants with altered mitochondrial morphology was followed; a function for the corresponding genes in the apoptotic process was assessed. MDM30 and DNM1, the genes encoding an F-box protein and the dynamin-related GTPase, respectively, are involved in triggering aging and apoptosis. In contrast, YME1, encoding a subunit of the mitochondrial inner membrane i-AAA proteinase complex, has a protective role in these processes. FIS1, the mitochondrial fission gene, might play a protective role after an apoptotic insult while it seems to promote cell death in aging cells.
对一些线粒体形态改变的酵母突变体在时序老化过程中和凋亡刺激后的细胞活力进行了跟踪；评估了相应基因在凋亡过程中的功能。MDM30和DNM1分别是编码F-box蛋白和动力蛋白相关GTP酶的基因，它们参与引发老化和凋亡。相反，编码线粒体内膜i-AAA蛋白酶复合体一个亚基的YME1在这些过程中具有保护作用。线粒体分裂基因FIS1在凋亡损伤后可能发挥保护作用，而在老化细胞中似乎促进细胞死亡。
