Scopinaro Francesco, Tofani Anna, di Santo Gianpaolo, Di Pietro Barbara, Lombardi Augusto, Lo Russo Marzia, Soluri Alessandro, Massari Roberto, Trotta Carlo, Amanti Claudio
Department of Radiological Sciences, La Sapienza University, Rome, Italy.
Cancer Biother Radiopharm. 2008 Feb;23(1):43-52. doi: 10.1089/cbr.2007.364.
The imaging probe (IP) is a high-resolution (HR), 1-in(2) field-of-view hand-held gamma camera. We used it to detect breast cancer sentinel node (SN).
We divided 120 T1 breast cancer patients, who underwent Anger camera lymphoscintigraphy (ACL), in two subgroups of 60 patients who were age, body mass index, and cancer size matched: subgroup A (SA) and B (SB). SN was detected with a common gamma probe (GP) in SA, with IP plus GP in SB.
Surgeons removed radioactive nodes without exceeding four nodes. Eighty-two (82) SNs were taken off in SA and 105 in SB (p<0.01). Of SA, 22 of 60 patients and 36 of 60 patients of SB showed more than 1 node, and 3 of them showed 3 nodes and 1 showed 4 nodes. Thirteen (13) patients resulted N(+) (21.6%) in SA. Ten (10) patients of SA showed an invasion on the hottest nodes and 3 on the second nodes. In the SB, 18 patients (25%) showed invasion. Sixteen (16) invasions were on hot, 4 on second, and 1 on the third node. Withdrawal time of SN was 11.25+/-4.7 minutes for SA and 7.4+/-2.8 minutes for SB (p<0.025).
SN biopsy with IP is fast and discovers more SNs and more invasions than ACL.
成像探头（IP）是一种高分辨率（HR）、视野为1平方英寸的手持式γ相机。我们用它来检测乳腺癌前哨淋巴结（SN）。
我们将120例行安格尔相机淋巴闪烁显像（ACL）的T1期乳腺癌患者分为两个亚组，每组60例，两组在年龄、体重指数和肿瘤大小方面相匹配：亚组A（SA）和亚组B（SB）。SA组用普通γ探头（GP）检测前哨淋巴结，SB组用IP加GP检测。
外科医生切除的放射性淋巴结不超过4个。SA组切除82个前哨淋巴结，SB组切除105个（p<0.01）。SA组60例患者中有22例、SB组60例患者中有36例显示有1个以上淋巴结，其中3例显示有3个淋巴结，1例显示有4个淋巴结。SA组13例患者（21.6%）前哨淋巴结阳性。SA组10例患者在最热点淋巴结有浸润，3例在第二热点淋巴结有浸润。SB组有18例患者（25%）显示有浸润。16例浸润发生在热点淋巴结，4例在第二热点淋巴结，1例在第三热点淋巴结。SA组前哨淋巴结取出时间为11.25±4.7分钟，SB组为7.4±2.8分钟（p<0.025）。
与ACL相比，使用IP进行前哨淋巴结活检速度更快，能发现更多前哨淋巴结和更多浸润情况。
