Uderzo C, Rovelli A, Bonomi M, Fomia L, Pirovano L, Masera G
Department of Pediatrics, University of Milan, Italy.
Eur J Cancer. 1991;27(6):758-62. doi: 10.1016/0277-5379(91)90183-e.
The aggressive radiotherapy and chemotherapy used in conditioning regimens for children with leukaemia undergoing bone marrow transplantation (BMT) cause a severe catabolic state. Total parenteral nutrition (TPN) is indispensable in the management of these patients. 25 children with leukaemia undergoing BMT were studied to evaluate the efficacy of TPN and the value of anthropometric parameters and biochemical variables (albumin, retinol-binding protein and prealbumin) in monitoring nutritional status in the critical post-BMT phase. The complications of TPN were mainly metabolic, generally mild and easily controlled. The hyperalimentation solution and infusion line were not responsible for infection in any patient. The marked variations in anthropometric parameters and albumin expected in such patients were not observed in our children due to the nutritional support given. Prealbumin and retinol-binding protein showed statistically significant, positive variations (P less than 0.01), thus proving sensitive indices of the response to nutritional repletion.
用于接受骨髓移植（BMT）的白血病患儿预处理方案中的强化放疗和化疗会导致严重的分解代谢状态。全胃肠外营养（TPN）在这些患者的管理中不可或缺。对25例接受BMT的白血病患儿进行了研究，以评估TPN的疗效以及人体测量参数和生化变量（白蛋白、视黄醇结合蛋白和前白蛋白）在监测BMT后关键阶段营养状况方面的价值。TPN的并发症主要是代谢性的，一般较轻且易于控制。高营养溶液和输液管未导致任何患者发生感染。由于给予了营养支持，我们的患儿未出现此类患者预期的人体测量参数和白蛋白的显著变化。前白蛋白和视黄醇结合蛋白显示出具有统计学意义的正向变化（P小于0.01），从而证明是营养补充反应的敏感指标。
