Madrazo José, García-Fernández Rosa A, García-Iglesias María J, Durán Alex J, Espinosa Javier, Pérez-Martínez Claudia
Pathological Anatomy Section, Animal Health Department, Veterinary School, University of León, 24007 León, Spain.
Vet J. 2009 Jun;180(3):371-6. doi: 10.1016/j.tvjl.2008.01.007. Epub 2008 Mar 4.
CD44 is an adhesion molecule implicated in the progression of human breast cancer. The purpose of this study was to describe CD44 antigen expression in canine mammary carcinomas and to evaluate its prognostic significance in relation to other clinico-pathological variables. A reduction in CD44 expression was significantly related to variables such as tumour size and adherence to underlying tissues but was not related to tumour location or to ulceration of the overlying skin. Complex (grade I) and anaplastic (grade III) carcinomas exhibited more intense expression of this antigen than did some tubulopapillary and most solid carcinomas (grade II). Although reduced CD44 expression was associated with infiltrative growth and vascular invasion in solid carcinomas, intense expression was also observed in anaplastic tumours. Although overall these findings suggest a role for this adhesion factor in canine mammary tumour development and progression, the complexity and apparently paradoxical nature of some of the findings currently limit the use of this immunohistochemical marker as a prognostic indicator.
CD44是一种与人类乳腺癌进展相关的黏附分子。本研究的目的是描述CD44抗原在犬乳腺癌中的表达情况，并评估其与其他临床病理变量相关的预后意义。CD44表达的降低与肿瘤大小和对深层组织的附着等变量显著相关，但与肿瘤位置或覆盖皮肤的溃疡无关。复杂型（I级）和间变型（III级）癌比一些管状乳头状癌和大多数实体癌（II级）表现出更强的该抗原表达。虽然CD44表达降低与实体癌的浸润性生长和血管侵犯有关，但在间变肿瘤中也观察到强表达。尽管总体而言这些发现表明这种黏附因子在犬乳腺肿瘤发生和进展中起作用，但目前一些发现的复杂性和明显矛盾的性质限制了这种免疫组化标记物作为预后指标的应用。
