Samanic Claudine M, De Roos Anneclaire J, Stewart Patricia A, Rajaraman Preetha, Waters Martha A, Inskip Peter D
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA.
Am J Epidemiol. 2008 Apr 15;167(8):976-85. doi: 10.1093/aje/kwm401. Epub 2008 Feb 24.
The authors examined incident glioma and meningioma risk associated with occupational exposure to insecticides and herbicides in a hospital-based, case-control study of brain cancer. Cases were 462 glioma and 195 meningioma patients diagnosed between 1994 and 1998 in three US hospitals. Controls were 765 patients admitted to the same hospitals for nonmalignant conditions. Occupational histories were collected during personal interviews. Exposure to pesticides was estimated by use of a questionnaire, combined with pesticide measurement data abstracted from published sources. Using logistic regression models, the authors found no association between insecticide and herbicide exposures and risk for glioma and meningioma. There was no association between glioma and exposure to insecticides or herbicides, in men or women. Women who reported ever using herbicides had a significantly increased risk for meningioma compared with women who never used herbicides (odds ratio = 2.4, 95% confidence interval: 1.4, 4.3), and there were significant trends of increasing risk with increasing years of herbicide exposure (p = 0.01) and increasing cumulative exposure (p = 0.01). There was no association between meningioma and herbicide or insecticide exposure among men. These findings highlight the need to go beyond job title to elucidate potential carcinogenic exposures within different occupations.
在一项基于医院的脑癌病例对照研究中，作者调查了职业性接触杀虫剂和除草剂与患胶质瘤和脑膜瘤风险之间的关联。病例为1994年至1998年间在美国三家医院确诊的462例胶质瘤患者和195例脑膜瘤患者。对照为因非恶性疾病入住同一家医院的765名患者。在个人访谈期间收集职业史。通过使用问卷估计农药接触情况，并结合从已发表资料中提取的农药测量数据。作者使用逻辑回归模型发现，接触杀虫剂和除草剂与患胶质瘤和脑膜瘤的风险之间没有关联。男性或女性的胶质瘤与接触杀虫剂或除草剂之间均无关联。报告曾使用除草剂的女性患脑膜瘤的风险显著高于从未使用过除草剂的女性（优势比=2.4，95%置信区间：1.4，4.3），并且随着除草剂接触年限的增加（p=0.01）和累积接触量的增加（p=0.01），风险呈显著上升趋势。男性的脑膜瘤与除草剂或杀虫剂接触之间无关联。这些发现凸显了超越职位名称来阐明不同职业中潜在致癌接触的必要性。
