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新型多烯抗真菌药SPK-843在小鼠系统性隐球菌病模型中的疗效

Efficacy of SPK-843, a novel polyene antifungal, in a murine model of systemic cryptococcosis.

作者信息

Kakeya Hiroshi, Miyazaki Yoshitsugu, Senda Hisato, Kobayashi Tsutomu, Seki Masafumi, Izumikawa Koichi, Yamamoto Yoshihiro, Yanagihara Kazunori, Tashiro Takayoshi, Kohno Shigeru

机构信息

Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.

出版信息

Antimicrob Agents Chemother. 2008 May;52(5):1871-2. doi: 10.1128/AAC.01370-07. Epub 2008 Feb 25.

DOI:10.1128/AAC.01370-07
PMID:18299408
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2346668/
Abstract

SPK-843, a new polyene antifungal, possessed efficacy in a murine model of systemic infection caused by Cryptococcus neoformans. The administration of 4.0 mg/kg SPK-843 led to better survival prolongation and fungal reduction than those observed with the administration of 0.7 mg/kg amphotericin B and 80 mg/kg fluconazole (P < 0.001), without histopathological renal changes.

摘要

新型多烯类抗真菌药物SPK-843在新型隐球菌引起的小鼠全身感染模型中具有疗效。给予4.0mg/kg的SPK-843比给予0.7mg/kg两性霉素B和80mg/kg氟康唑能更好地延长生存期并减少真菌量（P<0.001），且无组织病理学上的肾脏改变。

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本文引用的文献

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Amphotericin B and fluconazole, a potent combination therapy for cryptococcal meningitis.两性霉素B和氟康唑，一种用于治疗隐球菌性脑膜炎的有效联合疗法。
Antimicrob Agents Chemother. 2004 Mar;48(3):985-91. doi: 10.1128/AAC.48.3.985-991.2004.
2
In vitro activity of a new polyene SPK-843 against Candida spp, Cryptococcus neoformans and Aspergillus spp clinical isolates.新型多烯类药物SPK-843对念珠菌属、新型隐球菌和曲霉属临床分离株的体外活性。
J Chemother. 2003 Jun;15(3):296-8. doi: 10.1179/joc.2003.15.3.296.
3
Comparative pharmacokinetics of three preparations of the new antifungal SPK-843.
Chemotherapy. 2001 Dec;47(6):387-95. doi: 10.1159/000048549.
4
Pharmacokinetics in rats of n-dimethylaminoacetyl-partricin a 2-dimethylaminoethylamide diascorbate (spk-843).
Chemotherapy. 2001 Mar-Apr;47(2):77-85. doi: 10.1159/000048504.
5
Preliminary study on in vitro activity and cytotoxicity on cell cultures of a new polyene antifungal molecule (SPA-S-843).
Eur J Pharm Biopharm. 1999 Mar;47(2):179-84. doi: 10.1016/s0939-6411(98)00065-4.
6
In vitro activity of a new polyene, SPA-S-843, against yeasts.新型多烯类化合物SPA-S-843对酵母的体外活性
Antimicrob Agents Chemother. 1998 Nov;42(11):3012-3. doi: 10.1128/AAC.42.11.3012.
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Infect Immun. 1997 May;65(5):1653-8. doi: 10.1128/iai.65.5.1653-1658.1997.