新型多烯类化合物SPA-S-843对酵母的体外活性
In vitro activity of a new polyene, SPA-S-843, against yeasts.
作者信息
Rimaroli C, Bruzzese T
机构信息
Research Laboratories, Società Prodotti Antibiotici SpA, 20143 Milan, Italy.
出版信息
Antimicrob Agents Chemother. 1998 Nov;42(11):3012-3. doi: 10.1128/AAC.42.11.3012.
Abstract
The in vitro activity of a new water-soluble polyene, SPA-S-843, was evaluated against 116 strains of Candida, Cryptococcus, and Saccharomyces spp. and compared with that of amphotericin B. SPA-S-843 demonstrated better inhibitory activity against all of the yeasts examined and better fungicidal activity against Candida albicans, Candida glabrata, Candida krusei, and Candida tropicalis than did amphotericin B.
摘要
对一种新型水溶性多烯SPA-S-843针对116株念珠菌、隐球菌和酿酒酵母属菌株的体外活性进行了评估，并与两性霉素B的活性进行了比较。与两性霉素B相比，SPA-S-843对所有检测的酵母均表现出更好的抑制活性，对白色念珠菌、光滑念珠菌、克柔念珠菌和热带念珠菌具有更好的杀菌活性。
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