Bashash M, Shah A, Hislop G, Brooks-Wilson A, Le N, Bajdik C
BC Cancer Agency, Vancouver, Canada.
Can J Gastroenterol. 2008 Feb;22(2):143-8. doi: 10.1155/2008/645107.
Geographical variation and temporal trends in the incidence of esophageal and gastric cancers vary according to both tumour morphology and organ subsite. Both diseases are among the deadliest forms of cancer. The incidence and survival rates for gastric and esophageal carcinoma in British Columbia (BC) between 1990 and 1999 are described.
Incidence data for the period 1990 to 1999 were obtained from the BC Cancer Registry. Age-adjusted incidence and survival rates were computed by anatomical subsite, histological type and sex. All rates were standardized to the 1996 Canadian population. The estimated annual percentage change (EAPC) was used to measure incidence changes over time. Kaplan-Meier curves were used to show survival rates, and log-rank tests were used to test for differences in the curves among various groups.
Between 1990 and 1999, 1741 esophageal cancer cases and 3431 gastric cancer cases were registered in BC. There was an increase in the incidence of adenocarcinoma of the esophagus over time (EAPC=9.6%) among men, and of gastric cardia cancer among both women (EAPC=9.2%) and men (EAPC=3.8%). Patients with proximal gastric (cardia) cancer had significantly better survival rates than patients with cancer in the lower one-third of the esophagus. Among gastric cancers, patients with distal tumours had a significantly better survival rate than patients with proximal tumours.
The incidences of proximal gastric cancer and esophageal adenocarcinoma are increasing, and their survival patterns are different. Examining these cancers together may elucidate new etiological and prognostic factors.
食管癌和胃癌发病率的地理差异及时空趋势因肿瘤形态和器官亚部位而异。这两种疾病均为最致命的癌症形式。本文描述了1990年至1999年不列颠哥伦比亚省（BC）胃癌和食管癌的发病率及生存率。
1990年至1999年期间的发病数据来自BC癌症登记处。按解剖亚部位、组织学类型和性别计算年龄调整发病率及生存率。所有发病率均根据1996年加拿大人口进行标准化。采用估计年变化百分比（EAPC）来衡量发病率随时间的变化。采用Kaplan-Meier曲线显示生存率，并采用对数秩检验来检验不同组间曲线的差异。
1990年至1999年期间，BC省登记了1741例食管癌病例和3431例胃癌病例。男性食管腺癌发病率随时间增加（EAPC=9.6%），女性（EAPC=9.2%）和男性（EAPC=3.8%）贲门癌发病率均增加。胃近端（贲门）癌患者的生存率明显高于食管下三分之一段癌症患者。在胃癌患者中，远端肿瘤患者的生存率明显高于近端肿瘤患者。
胃近端癌和食管腺癌的发病率在增加，且其生存模式不同。将这些癌症放在一起研究可能会阐明新的病因和预后因素。
