PAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong, BE1410, Brunei Darussalam.
The Brunei Cancer Centre, Pantai Jerudong Specialist Centre, Bandar Seri Begawan, Brunei.
J Gastrointest Cancer. 2022 Mar;53(1):130-143. doi: 10.1007/s12029-020-00559-w. Epub 2021 Jan 4.
Oesophagogastric cancer is one of the leading causes of cancer death worldwide due to its aggressive nature. Despite the high mortality rate, there is limited information regarding this cancer in Brunei.
To estimate the incidence and survival duration of oesophagogastric cancer patients, to identify prognostic factors of oesophagogastric cancer and associated factors for late-stage oesophagogastric cancer detection.
A retrospective study on all oesophagogastric cancer patients registered in the population-based national cancer registry in Brunei from January 2010 to December 2018. Kaplan-Meier and Cox proportional hazard regression survival analyses and multiple logistic regression were applied.
Sixty-eight oesophagogastric cancer patients' data were retrieved from the registry. The incidence was 2.75 cases per 100,000 adults per year. Median survival time was 1.18 years (95% CI: 0.77, 1.80) and the 3-year survival rate was 26.3%. Age (61-70 years) (adjusted HR = 0.38; 95% CI: 0.17, 0.89; p = 0.025) and those who have undergone chemotherapy (adj. HR = 0.40; 95% CI: 0.18, 0.90; p = 0.026) have a significantly lower mortality risk. Obesity (adj. HR = 11.94; 95% CI: 1.94, 73.36; p = 0.007), and stage 4 (advanced stage) cancer (adj. HR=4.11; 95% CI: 1.97, 8.58; p< 0.001) have a significantly higher mortality risk. Females have 3-time odds (adj. OR = 3.05; 95% CI: 1.09, 9.02; p = 0.038) of presenting with stage 4 cancer. Smokers have 13-time odds (Adj. OR=12.99; 95% CI: 1.92, 262.0; p = 0.025) of presenting with stage 4 cancer.
Prognosis of oesophagogastric cancer remains poor. Addressing late detection and improve endoscopic surveillance and awareness of symptoms may help improve prognosis and mortality.
由于其侵袭性，胃癌是全球导致癌症死亡的主要原因之一。尽管死亡率很高，但文莱对这种癌症的了解有限。
估计胃癌患者的发病率和生存时间，确定胃癌的预后因素和晚期胃癌检测的相关因素。
对 2010 年 1 月至 2018 年 12 月期间在文莱全国癌症登记处登记的所有胃癌患者进行回顾性研究。应用 Kaplan-Meier 和 Cox 比例风险回归生存分析和多因素逻辑回归。
从登记处检索到 68 名胃癌患者的数据。发病率为每 10 万人中每年 2.75 例。中位生存时间为 1.18 年（95%CI：0.77，1.80），3 年生存率为 26.3%。年龄（61-70 岁）（调整 HR = 0.38；95%CI：0.17，0.89；p = 0.025）和接受化疗的患者（adj. HR = 0.40；95%CI：0.18，0.90；p = 0.026）的死亡率明显较低。肥胖（adj. HR = 11.94；95%CI：1.94，73.36；p = 0.007）和 4 期（晚期）癌症（adj. HR = 4.11；95%CI：1.97，8.58；p<0.001）的死亡率明显较高。女性患 4 期癌症的几率是男性的 3 倍（adj. OR = 3.05；95%CI：1.09，9.02；p = 0.038）。吸烟者患 4 期癌症的几率是不吸烟者的 13 倍（adj. OR=12.99；95%CI：1.92，262.0；p = 0.025）。
胃癌的预后仍然很差。解决晚期发现问题，改善内镜监测和症状意识可能有助于改善预后和死亡率。
