Müller C, Wolf H, Göttlicher J, Eibl M M
Dept. of Gastroenterology and Hepatology II, University of Vienna, Austria.
Scand J Gastroenterol. 1991 Mar;26(3):295-301. doi: 10.3109/00365529109025045.
Peripheral blood lymphocytes from patients with alcoholic cirrhosis, alcohol-induced fatty liver, and healthy controls were analyzed for helper-inducer (CD4+CD29w+) and suppressor-inducer (CD4+CD45R+) T lymphocytes. In confirmation of earlier reports, patients with alcoholic cirrhosis were found to have a significantly reduced absolute number of peripheral lymphocytes (p = 0.03), an elevated relative percentage of CD3+ cells (median, 76% versus 68%; p = 0.0004) and CD4+ T cells (median, 56% versus 51%; p = 0.0011), and a reduced percentage of CD8+ T lymphocytes (median, 11% versus 20%; p = 0.0007) as compared with the control group. No difference in lymphocyte subsets was observed between controls and patients with alcohol-induced fatty liver. Within the CD4+ T-cell population a change in the relative proportion of two complementary lymphocyte subsets (CD4+CD29+ helper-inducer and CD4+CD45R+ suppressor-inducer T cells) was observed in patients with alcoholic cirrhosis: a higher percentage of CD4+CD29w+ helper-inducer T cells were circulating in their peripheral blood than in healthy controls (median, 33% versus 28%; p = 0.0036), whereas the CD4+CD45R+ suppressor-inducer T-cell subset did not differ (median, 21% versus 21%) between the two groups. Owing to the reduction of lymphocyte counts in cirrhotic patients the absolute number of CD4+CD29w+ cells was not different from that of control individuals; however, CD4+CD45R+ T cells in peripheral blood (p = 0.0063) were absolutely reduced. More CD4+ cells were simultaneously CD29w+ in cirrhotic patients (61%) than in controls (52%), whereas a lower percentage of CD4+ lymphocytes was also CD45R+ in these patients (33%) as compared with controls (40%).(ABSTRACT TRUNCATED AT 250 WORDS)
对酒精性肝硬化患者、酒精性脂肪肝患者及健康对照者的外周血淋巴细胞进行辅助诱导型（CD4 + CD29w +）和抑制诱导型（CD4 + CD45R +）T淋巴细胞分析。正如早期报告所证实的，与对照组相比，酒精性肝硬化患者外周淋巴细胞绝对数量显著减少（p = 0.03），CD3 + 细胞（中位数，76% 对 68%；p = 0.0004）和CD4 + T细胞（中位数，56% 对 51%；p = 0.0011）的相对百分比升高，而CD8 + T淋巴细胞百分比降低（中位数，11% 对 20%；p = 0.0007）。酒精性脂肪肝患者与对照者之间未观察到淋巴细胞亚群的差异。在酒精性肝硬化患者的CD4 + T细胞群体中，观察到两种互补淋巴细胞亚群（CD4 + CD29 + 辅助诱导型和CD4 + CD45R + 抑制诱导型T细胞）的相对比例发生变化：与健康对照者相比，其外周血中循环的CD4 + CD29w + 辅助诱导型T细胞百分比更高（中位数，33% 对 28%；p = 0.0036），而两组间CD4 + CD45R + 抑制诱导型T细胞亚群无差异（中位数，21% 对 21%）。由于肝硬化患者淋巴细胞计数减少，CD4 + CD29w + 细胞的绝对数量与对照个体无差异；然而，外周血中的CD4 + CD45R + T细胞绝对数量减少（p = 0.0063）。与对照者（52%）相比，肝硬化患者中同时为CD29w + 的CD4 + 细胞更多（61%），而这些患者中同时为CD45R + 的CD4 + 淋巴细胞百分比（33%）低于对照者（40%）。（摘要截选于250字）
