Choi Hee-Baeg, Roh Sang-Young, Choi Eun-Jung, Yoon Ho-Yeul, Kim Su-Yeon, Hong Young-Sun, Kim Dong-Wook, Kim Tai-Gyu
Catholic Hemopoietic Stem Cell Bank, Department of Microbiology, College of Medicine, The Catholic University of Korea, 505 Banpo-Dong, Seocho-Ku, Seoul, 137-701, South Korea.
Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, 137-701, South Korea.
Int J Hematol. 2008 Mar;87(2):203-209. doi: 10.1007/s12185-008-0040-4. Epub 2008 Feb 27.
Several studies have been performed on the association between non-Hodgkin's lymphoma (NHL) and the presence of certain human leukocyte antigens (HLA) class II alleles in Asian countries, and these studies have shown different results, according to the ethnicity, for the frequencies of the HLA class II alleles, and especially for HLA-DRB1. Therefore, the distribution of the HLA-A, B, C, DRB1, and DQB1 alleles in 89 Korean patients with NHL and also in 200 healthy Korean controls was investigated in this study. For the class I alleles, the frequencies of HLA-B51 was increased in patients with NHL and diffuse large B cell (DLBC) lymphoma compared with the normal control. For the class II alleles, the frequencies of the HLA-DRB109 and DQB103 alleles were increased in patients with NHL and DLBC lymphoma compared with the normal controls. Also, the B51-DRB109-DQB103 haplotype was significantly increased in the patients with NHL. These results suggest that some genes in HLA-B51-DRB109-DQB1*03 haplotype may contribute to NHL susceptibility in the Korean population.
在亚洲国家，已经针对非霍奇金淋巴瘤（NHL）与某些人类白细胞抗原（HLA）II类等位基因的存在之间的关联开展了多项研究，这些研究表明，根据种族不同，HLA II类等位基因的频率，尤其是HLA-DRB1的频率，呈现出不同的结果。因此，本研究调查了89例韩国NHL患者以及200例健康韩国对照中HLA-A、B、C、DRB1和DQB1等位基因的分布情况。对于I类等位基因，与正常对照相比，NHL患者和弥漫性大B细胞（DLBC）淋巴瘤患者中HLA-B51的频率有所增加。对于II类等位基因，与正常对照相比，NHL患者和DLBC淋巴瘤患者中HLA-DRB109和DQB103等位基因的频率有所增加。此外，NHL患者中B51-DRB109-DQB103单倍型显著增加。这些结果表明，HLA-B51-DRB109-DQB1*03单倍型中的某些基因可能导致韩国人群对NHL易感。
