Nørgaard K, Feldt-Rasmussen B, Deckert T
Steno Memorial Hospital, Gentofte, Denmark.
Diabet Med. 1991 May;8(4):334-7. doi: 10.1111/j.1464-5491.1991.tb01606.x.
Hypertension is an established risk factor for retinopathy. Whether it is an independent risk factor or acts only by association with nephropathy is not known. Therefore, we studied 273 Type 1 diabetic patients. They were divided into four groups. Group 1 (n = 55) were normotensive and normoalbuminuric, group 2 (n = 51) had hypertension but were normoalbuminuric, group 3 (n = 33) had nephropathy but were normotensive, and group 4 (n = 134) had nephropathy and hypertension. Hypertensive patients with normoalbuminuria (blood pressure 146 +/- 19 (+/-SD)/87 +/- 12 mmHg) had the same prevalence of retinopathy as normoalbuminuric normotensive patients (123 +/- 12/75 +/- 5 mmHg). Hypertensive nephropathic patients (blood pressure 147 +/- 18/87 +/- 8 mmHg) had more retinopathy than hypertensive normoalbuminuric patients despite similar blood pressure (normal retina/advanced retinopathy: 3%/73% vs 46%/17%, p less than 0.001). Nephropathic normotensive patients had worse retinal changes than hypertensive normoalbuminuric patients (19%/49%, p less than 0.001) but fewer than the nephropathic hypertensive patients p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
高血压是视网膜病变已确定的危险因素。它是一个独立的危险因素，还是仅通过与肾病相关联起作用尚不清楚。因此，我们研究了273例1型糖尿病患者。他们被分为四组。第1组（n = 55）血压正常且尿白蛋白正常，第2组（n = 51）患有高血压但尿白蛋白正常，第3组（n = 33）患有肾病但血压正常，第4组（n = 134）患有肾病且患有高血压。尿白蛋白正常的高血压患者（血压146±19（±标准差）/87±12 mmHg）与尿白蛋白正常且血压正常的患者（123±12/75±5 mmHg）视网膜病变患病率相同。尽管血压相似，但高血压肾病患者（血压147±18/87±8 mmHg）比高血压尿白蛋白正常的患者有更多的视网膜病变（正常视网膜/晚期视网膜病变：3%/73% 对 46%/17%，p<0.001）。血压正常的肾病患者比高血压尿白蛋白正常的患者有更严重的视网膜改变（19%/49%，p<0.001），但比肾病高血压患者少（p<0.001）。（摘要截断于250字）
