Galassi Fernando, Giambene Barbara
Eye Clinic, University of Florence, Italy.
J Glaucoma. 2008 Jan-Feb;17(1):52-6. doi: 10.1097/IJG.0b013e3180d0a885.
To evaluate the results of deep sclerectomy with SkGel at 3 and 5 years.
This retrospective trial comprised 200 eyes with open angle glaucoma having a 3-year follow-up, 97 having a 5-year follow-up. Visual acuity, intraocular pressure (IOP), and slit-lamp examination were recorded at baseline and at follow-up visits. Visual field (VF) testing was repeated every 6 months.
Mean IOP decreased from 21.01+/-5.56 mm Hg before surgery to 13.13+/-2.24 mm Hg at 36 months and from 20.61+/-5.50 to 12.85+/-1.84 mm Hg at 60 months (P<0.0005). At 3 and 5 years, complete success rates (IOP<or=16 mm Hg without medications) were 67.50% and 64.95%, partial success rates were (IOP<or=16 mm Hg with medications) 21.50% and 24.74%, and failure rates were (IOP>16 mm Hg) 11% and 10.31%, respectively. VF testing revealed stable mean deviation and corrected pattern standard deviation values at 3 and 5 years (P>0.05). At 3 years, success rate was greater if goniopuncture was performed within 3 months after surgery (P=0.022). Complications of the surgery were not observed after goniopunctures.
Deep sclerectomy with SkGel provides stable control of IOP and VF.
评估使用SkGel进行深层巩膜切除术3年和5年的效果。
这项回顾性试验纳入了200例开角型青光眼患者的眼睛，其中97例进行了5年随访，其余103例进行了3年随访。在基线和随访时记录视力、眼压（IOP）和裂隙灯检查结果。每6个月重复进行一次视野（VF）测试。
平均眼压从手术前的21.01±5.56 mmHg降至36个月时的13.13±2.24 mmHg，以及60个月时的12.85±1.84 mmHg（P<0.0005）。在3年和5年时，完全成功率（不用药眼压≤16 mmHg）分别为67.50%和64.95%，部分成功率（用药眼压≤16 mmHg）分别为21.50%和24.74%，失败率（眼压>16 mmHg）分别为11%和10.31%。VF测试显示在3年和5年时平均偏差和校正模式标准差的值稳定（P>0.05）。在3年时，如果在手术后3个月内进行前房穿刺，成功率更高（P=0.022）。前房穿刺后未观察到手术并发症。
使用SkGel进行深层巩膜切除术可稳定控制眼压和视野。
