前列腺癌的全球流行病学：尸检研究的视角
The worldwide epidemiology of prostate cancer: perspectives from autopsy studies.
作者信息
Haas Gabriel P, Delongchamps Nicolas, Brawley Otis W, Wang Ching Y, de la Roza Gustavo
机构信息
Department of Urology, SUNY Upstate Medical University, Syracuse, New York 13210, USA.
出版信息
Can J Urol. 2008 Feb;15(1):3866-71.
INTRODUCTION
Prostate cancer is the most frequently diagnosed non-skin cancer in the United States and the third leading cause of cancer deaths. International trends in the incidence, mortality and prevalence of prostate cancer are assessed.
METHODS
Databases from the Surveillance, Epidemiology and End Results (SEER) program of the National Cancer Institute and the International Agency for Research on Cancer (IARC), and the literature on autopsy studies on prostate cancer were reviewed and summarized in the article.
RESULTS
Prostate cancer remains an important public health concern in Western countries and an emerging malignancy in developing nations. Prostate cancer incidence is dependent on efforts to detect the disease. Autopsy studies provide accurate and useful information regarding comparative prevalence rates of the disease among regions of interest.
CONCLUSIONS
Improved cancer registration is needed in developing nations. The prevalence of prostate cancer must be established to predict the expected incidence of the disease and in order to plan rational detection and treatment strategies. Clinically significant disease should be distinguished from insignificant disease which may pose little or no biological danger to the patient.
引言
前列腺癌是美国最常被诊断出的非皮肤癌，也是癌症死亡的第三大主要原因。本文评估了前列腺癌发病率、死亡率和患病率的国际趋势。
方法
文章回顾并总结了美国国立癌症研究所监测、流行病学和最终结果（SEER）计划以及国际癌症研究机构（IARC）的数据库，以及有关前列腺癌尸检研究的文献。
结果
前列腺癌在西方国家仍然是一个重要的公共卫生问题，在发展中国家则是一种新兴的恶性肿瘤。前列腺癌的发病率取决于疾病检测的力度。尸检研究为感兴趣区域之间该疾病的比较患病率提供了准确且有用的信息。
结论
发展中国家需要改进癌症登记工作。必须确定前列腺癌的患病率，以预测该疾病的预期发病率，并制定合理的检测和治疗策略。应将具有临床意义的疾病与对患者几乎没有或没有生物学危险的无意义疾病区分开来。
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