Fenichel Rebecca M, Dominguez Jennifer E, Mayer Laurel, Walsh B Timothy, Boozer Carol, Warren Michelle P
Department of Obstetrics and Gynecology, Columbia College of Physicians and Surgeons, New York, New York 10032, USA.
Fertil Steril. 2008 Oct;90(4):1161-8. doi: 10.1016/j.fertnstert.2007.07.1350. Epub 2008 Mar 4.
To determine whether leptin and LH secretion in normal women is related to changes in metabolic rate.
Academic medical center. PATIENT(S) AND DESIGN: Ten young women with normal weight and menses were studied during the early follicular phase. Leptin and LH levels were sampled every 15 minutes over a 24-hour period. Metabolic rate was frequently sampled using indirect calorimetry. Luteinizing hormone pulsatility was analyzed using a Cluster Program analysis.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Leptin, LH, and metabolic rate levels.
RESULT(S): All subjects demonstrated a diurnal leptin curve. Luteinizing hormone pulses were increased in amplitude and slower after the leptin peak. The average (+/-SE) number of LH pulses per 6 hours slowed from 4.30 +/- 0.42 to 3.00 +/- 0.42 pulses after the leptin peak, whereas pulse amplitude increased from 1.64 +/- 0.26 to 2.51 +/- 0.42 mIU/mL after the leptin peak. The LH interpulse interval increased from 85.1 +/- 3.64 minutes to 108.8 +/- 10.26 minutes after the leptin peak. Metabolic rate began to drop approximately 4-6 hours before leptin levels peaked, going from 1.66 +/- 0.24 to 1.15 +/- 0.04 kcal/min after the leptin peak.
CONCLUSION(S): There is a significant association between the timing of the leptin peak, the nightly slowing of LH pulses, and the fall in metabolic rate, suggesting a metabolic cycle in normal individuals.
确定正常女性体内瘦素和促黄体生成素（LH）的分泌是否与代谢率变化有关。
学术医学中心。
对10名体重和月经正常的年轻女性在卵泡早期进行研究。在24小时内每15分钟采集一次瘦素和LH水平。使用间接测热法频繁采集代谢率数据。使用聚类程序分析法分析促黄体生成素的脉冲性。
无。
瘦素、LH和代谢率水平。
所有受试者均呈现出昼夜瘦素曲线。瘦素峰值出现后，促黄体生成素脉冲的幅度增加且频率减慢。瘦素峰值出现后，每6小时LH脉冲的平均（±标准误）数量从4.30±0.42次减慢至3.00±0.42次，而脉冲幅度从1.64±0.26 mIU/mL增加至2.51±0.42 mIU/mL。瘦素峰值出现后，LH脉冲间期从85.1±3.64分钟增加至108.8±10.26分钟。代谢率在瘦素水平达到峰值前约4 - 6小时开始下降，瘦素峰值出现后从1.66±0.24 kcal/min降至1.15±0.04 kcal/min。
瘦素峰值出现的时间、夜间LH脉冲频率减慢与代谢率下降之间存在显著关联，提示正常个体存在代谢周期。
