Yang Yun-Liang, Wang An-Huei, Wang Chih-Wei, Cheng Wei-Ting, Li Shu-Ying, Lo Hsiu-Jung
Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan, ROC.
Diagn Microbiol Infect Dis. 2008 Jun;61(2):175-80. doi: 10.1016/j.diagmicrobio.2008.01.011. Epub 2008 Mar 4.
Susceptibilities to amphotericin B and fluconazole of 964 Candida isolates collected in Taiwan Surveillance of Antimicrobial Resistance of Yeasts in 2006 were determined. There were 419 (43.5%) Candida albicans, 246 (25.5%) Candida tropicalis, 211 (21.9%) Candida glabrata, 62 (6.4%) Candida parapsilosis, 14 (1.5%) Candida krusei, and 12 (1.2%) others. Interestingly, 16 of the 17 amphotericin B-resistant isolates were non-albicans Candida species. The resistant rate to amphotericin B has decreased from 2.5% in 2002 to 1.8% in 2006. On the other hand, there were 132 C. tropicalis, 14 C. krusei, 10 C. albicans, and 9 C. glabrata isolates that had MICs to fluconazole > or =64 microg/mL. The prevalence of isolates with such high MICs was significantly higher than that in 2002 (17.1% versus 1.9%). Our results further indicate that most of the isolates with MICs to fluconazole > or =64 microg/mL exhibited the "trailing" phenomenon.
对2006年台湾地区酵母菌耐药性监测中收集的964株念珠菌分离株进行了两性霉素B和氟康唑敏感性测定。其中白色念珠菌419株（43.5%），热带念珠菌246株（25.5%），光滑念珠菌211株（21.9%），近平滑念珠菌62株（6.4%），克柔念珠菌14株（1.5%），其他12株（1.2%）。有趣的是，17株对两性霉素B耐药的分离株中有16株为非白色念珠菌。两性霉素B的耐药率已从2002年的2.5%降至2006年的1.8%。另一方面，有132株热带念珠菌、14株克柔念珠菌、10株白色念珠菌和9株光滑念珠菌对氟康唑的最低抑菌浓度（MIC）≥64μg/mL。此类高MIC分离株的流行率显著高于2002年（17.1%对1.9%）。我们的结果进一步表明，大多数对氟康唑MIC≥64μg/mL的分离株表现出“拖尾”现象。
