McCulloch C A, Bordin S
Faculty of Dentistry, University of Toronto, Canada.
J Periodontal Res. 1991 May;26(3 Pt 1):144-54. doi: 10.1111/j.1600-0765.1991.tb01638.x.
Fibroblasts are the principal cell type in the soft connective tissues of the periodontium; they perform important functions in development, physiology, and disease. A growing number of reports have indicated site-specific phenotypic variation of fibroblasts. Heterogeneity of metabolic traits has been demonstrated in cells from healthy and diseased tissues. The tissue distribution and relative proportions of fibroblast subpopulations have a significant impact on the regulation of connective tissue function in health and disease.
