Unsal Berrin, Saygun Işil, Daltaban Ozlem, Bal Belgin, Bolu Erol
Department of Periodontology, Gazi University, Faculty of Dentistry, Ankara, Turkey.
Yonsei Med J. 2008 Feb 29;49(1):71-8. doi: 10.3349/ymj.2008.49.1.71.
The aim of this preliminary study was to determine the possible relationship between alkaline phosphatase (ALP) levels in the gingival crevicular fluid (GCF) and periodontal disease in men with hypergonadotropic hypogonadism (HH).
A total of 41 patients were divided into four groups. 9 with HH and periodontitis (P/HH), 11 with HH and gingivitis (G/HH), 12 with systemically healthy and periodontally healthy (H/C) and 9 with systemically healthy and periodontitis (P/C). The clinical evaluation of patients was based on the following parameters; the plaque index (PI), gingival index (GI), probing depths (PD) and attachment level (AL). The levels of ALP in the GCF were measured by enzyme-linked immunosorbent assay (ELISA).
No significant difference could be detected in the mean clinical parameter data between the P/HH and P/C groups (p > 0.05). The periodontitis patients in both groups (P/C and P/HH) had higher mean probing depths than the H/C and G/HH patients (p < 0.001). The concentrations and total amounts of ALP in the GCF were significantly higher in both periodontitis groups compared to healthy and gingivitis groups (p < 0.01). The serum ALP levels were significantly higher in the P/HH group when compared to the other groups (p < 0.001).
The findings of this study suggested that HH could be implicated as a contributing factor to the progress of periodontal disease.
本初步研究的目的是确定促性腺激素分泌过多性性腺功能减退（HH）男性患者龈沟液（GCF）中碱性磷酸酶（ALP）水平与牙周疾病之间的可能关系。
共41例患者分为四组。9例患有HH和牙周炎（P/HH），11例患有HH和牙龈炎（G/HH），12例全身健康且牙周健康（H/C），9例全身健康且患有牙周炎（P/C）。患者的临床评估基于以下参数：菌斑指数（PI）、牙龈指数（GI）、探诊深度（PD）和附着水平（AL）。通过酶联免疫吸附测定（ELISA）测量GCF中ALP的水平。
P/HH组和P/C组之间的平均临床参数数据未检测到显著差异（p>0.05）。两组牙周炎患者（P/C和P/HH）的平均探诊深度均高于H/C组和G/HH组患者（p<0.001）。与健康组和牙龈炎组相比，两个牙周炎组GCF中ALP的浓度和总量均显著更高（p<0.01）。与其他组相比，P/HH组的血清ALP水平显著更高（p<0.001）。
本研究结果表明，HH可能是牙周疾病进展的一个促成因素。
