Patel Mandakini Mansukh, Modi Jigna P, Patel Sharmistha M, Patel R D
Department of Pathology, Government Medical College, Majuragate, Surat, Gujarat.
Indian J Pathol Microbiol. 2007 Oct;50(4):914-6.
Mortality in sickle cell disease is high at young age group. So it is necessary to find out the cause of death in young patients with sickle cell disease. We are presenting 5 cases of sudden death in young adults with undiagnosed sickle cell disease. The provocative factors for those terminal events were vasoocclusive crisis. In our patients crisis was secondary to fever (infection), conductive arrhythmia, cardiovascular collapse, post partum shock and hemorrhage. On microscopic examination of viscera, not a single patient showed signs of chronic organ damage, sequestration crisis or acute chest syndrome, which are the common causes of death in sickle cell disease.
镰状细胞病在年轻人群中的死亡率很高。因此，有必要找出镰状细胞病年轻患者的死因。我们报告了5例患有未确诊镰状细胞病的年轻成年人猝死病例。这些终末事件的诱发因素是血管阻塞性危机。在我们的患者中，危机继发于发热（感染）、传导性心律失常、心血管衰竭、产后休克和出血。对内脏进行显微镜检查时，没有一名患者表现出慢性器官损伤、脾滞留危机或急性胸综合征的迹象，而这些是镰状细胞病常见的死亡原因。
