他克莫司诱发的间质性肺炎类风湿关节炎患者的肺损伤。
Tacrolimus-induced lung injury in a rheumatoid arthritis patient with interstitial pneumonitis.
作者信息
Miwa Yusuke, Isozaki Takeo, Wakabayashi Kuninobu, Odai Tsuyoshi, Matsunawa Mizuho, Yajima Nobuyuki, Negishi Masao, Ide Hirotsugu, Kasama Tsuyoshi, Adachi Mitsuru, Hisayuki Tomoyuki, Takemura Tamiko
机构信息
Division of Rheumatology and Clinical Immunology, First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
出版信息
Mod Rheumatol. 2008;18(2):208-11. doi: 10.1007/s10165-008-0034-3. Epub 2008 Feb 29.
A 74-year-old woman was experiencing rheumatoid arthritis complicated with interstitial pneumonitis (IP), and tacrolimus treatment was started. She presented with dyspnea. Chest X-ray and computed tomography (CT) showed ground-glass opacity and IP. Although tacrolimus was stopped, she died of respiratory failure. At autopsy, both the upper and lower lung fields showed usual IP and the organizing stage of diffuse alveolar damage. The former is common, but the latter is uncommon, suggesting tacrolimus may cause severe alveolar damage.
一名74岁女性患有类风湿性关节炎并发间质性肺炎（IP），开始使用他克莫司进行治疗。她出现了呼吸困难。胸部X线和计算机断层扫描（CT）显示磨玻璃影和间质性肺炎。尽管停用了他克莫司，但她死于呼吸衰竭。尸检时，双肺野均显示普通型间质性肺炎和弥漫性肺泡损伤的机化期。前者常见，而后者不常见，提示他克莫司可能导致严重的肺泡损伤。
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