Karagiannis Emmanouil D, Popel Aleksander S
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
J Cell Biochem. 2008 Jul 1;104(4):1356-63. doi: 10.1002/jcb.21712.
Angiogenesis is tightly regulated by numerous endogenous pro- and anti-angiogenic proteins and peptides. Among these are the CXC chemokines, a set of multifunctional peptides. CXC chemokines containing the ELR motif act as pro-angiogenic agents by regulating both endothelial cell proliferation and migration. Here we show that a set of six 22-24-amino acid peptides derived from the pro-angiogenic ELR-containing CXC chemokines exhibit notable anti-proliferative and anti-migratory activity in vitro; we call these peptides chemokinostatins. The ability of the identified peptides to inhibit the basic components of angiogenesis even though they are derived from pro-angiogenic proteins contributes towards the understanding of the diverse role of the CXC chemokine family in angiogenesis.
血管生成受到多种内源性促血管生成和抗血管生成蛋白及肽的严格调控。其中包括CXC趋化因子，这是一组多功能肽。含有ELR基序的CXC趋化因子通过调节内皮细胞的增殖和迁移而作为促血管生成因子发挥作用。在此，我们表明，一组源自含ELR的促血管生成CXC趋化因子的六个22 - 24个氨基酸的肽在体外表现出显著的抗增殖和抗迁移活性；我们将这些肽称为趋化因子抑制素。尽管所鉴定的肽源自促血管生成蛋白，但它们抑制血管生成基本成分的能力有助于理解CXC趋化因子家族在血管生成中的多种作用。
