[The effect of N2O on the oxidative phosphorylation of the heart, liver, brain and kidney mitochondria and the ATPase activity of myocardial actomyosin].

The effect of various N2O concentrations on oxidation-phosphorylation, content and relationship of cytochromes in heart, liver, kidney and brain mitochondria and ATP-ase activity of myocardial actomyosin has been studied in the experiments on 180 white rats. It has been shown that N2O has distinct effect on oxidation-phosphorylation in mitochondria of the above organs. The most marked changes were observed in the myocardium and liver. However, the inhibition of tissue respiration noted and the rate of phosphorylation was not accompanied by a decrease in phosphorylation efficacy, which is indicative of great reserves of the mitochondrial oxidation chain and the reversibility of the occurring shifts. The absence of shifts in cytochrome system in response to the inhibition of mitochondrial oxidation in different conditions demonstrate that metabolic effect of N2O is manifested in NAD-dependent regions of the respiratory chain.