Glans F, Elgzyri T, Shaat N, Lindholm E, Apelqvist J, Groop L
Department of Clinical Sciences, University Hospital UMAS, Lund University, Lund, Sweden.
Diabet Med. 2008 Mar;25(3):303-7. doi: 10.1111/j.1464-5491.2007.02366.x.
To compare the clinical characteristics of Type 2 diabetes (T2DM) between immigrants from the Middle-East and Swedish patients.
The study group included 450 consecutive patients with T2DM, 379 Swedish-born aged 61 +/- 12 years and 71 patients originally from the Middle-East aged 50 +/- 11 years from the diabetes clinic of Malmo University Hospital.
Onset of diabetes had occurred 12 years earlier in the Middle-East immigrants compared with the Swedish-born patients (43 +/- 10 vs. 55 +/- 12 years, P < 0.001). Immigrants had lower fasting serum C-peptide [0.7 (0.1-2.6) vs. 0.9 (0.1-4.0) nmol/l, P = 0.013], lower homeostasis model assessment (HOMA)-beta[1.7 (0.1-9.1) vs. 2.7 (0.1-59.0), P = 0.010], lower HOMA-IR [0.4 (0.02-1.19) vs. 0.4 (0.01-2.8), P = 0.005] than the Swedish group. A first-degree family history of diabetes was reported in 61% of immigrants, compared with 47% of Swedish-born (P = 0.022).
Immigrants from the Middle-East have an earlier onset, stronger family history and more rapid decline of pancreatic B-cell function than Swedish patients, suggesting that they have a different form of T2DM compared with Swedish patients.
比较中东移民与瑞典患者2型糖尿病（T2DM）的临床特征。
研究组包括450例连续性T2DM患者，其中379例为出生在瑞典、年龄61±12岁的患者，以及71例原来自中东、年龄50±11岁的患者，均来自马尔默大学医院糖尿病诊所。
中东移民糖尿病发病时间比瑞典出生的患者早12年（43±10岁对55±12岁，P<0.001）。移民的空腹血清C肽水平较低[0.7（0.1 - 2.6）对0.9（0.1 - 4.0）nmol/L，P = 0.013]，稳态模型评估（HOMA）-β较低[1.7（0.1 - 9.1）对2.7（0.1 - 59.0），P = 0.010]，HOMA-IR较低[0.4（0.02 - 1.19）对0.4（0.01 - 2.8），P = 0.005]。61%的移民报告有糖尿病一级家族史，而瑞典出生的患者为47%（P = 0.022）。
与瑞典患者相比，中东移民糖尿病发病更早，家族史更强，胰腺β细胞功能下降更快，提示他们与瑞典患者的T2DM形式不同。
