[血小板与偏头痛。血小板聚集的生化标志物与血清素之间的相关性]

[Platelets and migraine. Correlation between biochemical markers of platelet aggregation and serotonin].

作者信息

Leira R, Castillo J, Martínez F, Castro A, Lema M, Noya M

机构信息

Servicio de Neurología, Hospital General de Galicia Clínico Universitario, Santiago de Compostela, La Coruña.

出版信息

Neurologia. 1991 Jan;6(1):10-2.

PMID:1830748

Abstract

The correlation between the biochemical markers of platelet activation and serotonin in migraine was investigated. The beta-thromboglobulin (beta-TG), platelet factor 4 (PF-4) and serotonin levels in 105 patients with migraine were measured. The results confirmed an increase in beta-TG and PF4 levels and a reduction in serotonin levels during the migraine attacks. However, we did not find a significant correlation between these fluctuations. These findings suggest the existence of extraplatelet mechanism in the pathophysiology of migraine.

摘要

研究了偏头痛患者血小板活化生化标志物与血清素之间的相关性。测定了105例偏头痛患者的β-血小板球蛋白（β-TG）、血小板因子4（PF-4）和血清素水平。结果证实，偏头痛发作期间β-TG和PF4水平升高，血清素水平降低。然而，我们并未发现这些波动之间存在显著相关性。这些发现提示偏头痛病理生理学中存在血小板外机制。