Kørner Ejnar Alex, Lauritzen Lise, Nilsson Flemming Mørkeberg, Wang August, Christensen Peder, Lolk Annette
Psykiatrisk Sygehus, Gerontopsykiatrisk Ambulatorium, Hillerød.
Ugeskr Laeger. 2008 Feb 25;170(9):745-9.
The Mini Mental State Examination (MMSE) is widely used in Denmark, but often in non-validated versions. In 2000 a cross-sectional workgroup decided on a new common version of the MMSE with a corresponding manual, which is validated for the first time in the present study.
The study was performed from April 2003 until August 2005 in four psycho-geriatric departments. The participants (65+ years) were assessed on three consecutive occasions (week 0, 1 and 26) with the MMSE (nurse), and global scales as well as diagnostically with ICD-10 (psycho-geriatrician).
101 persons were included, 29 were healthy, non-demented; 82 participants were assessed at visit two, 90 at visit three, but only 88 ratings were useable. The best cut-off value for the MMSE was > or = 26. Inter-rater and test-retest (r=0.91) correlations of the MMSE were high as were the correlations to the global scales. However, there were considerable variations in mean score (+/-SD) as well as median score and range in relation to CGI and GDS values. The MMSE score is independent of sex and educational level.
The MMSE also proved to be a robust scale in the present Danish version. It achieved excellent inter-rater and test-retest reliability. A cut-off value of = 26 proved better than 24 which was preferred hitherto. However, the ranges of the MMSE scores are so dispersed within the same global degree of severity that the MMSE should not generally be used to describe the severity of dementia disorders.
简易精神状态检查表（MMSE）在丹麦被广泛使用，但通常使用的是未经验证的版本。2000年，一个横断面工作组确定了MMSE的一个新的通用版本及相应手册，本研究首次对其进行验证。
该研究于2003年4月至2005年8月在四个老年精神科进行。参与者（65岁及以上）连续三次（第0周、第1周和第26周）接受MMSE评估（由护士进行）、整体量表评估以及由老年精神科医生按照国际疾病分类第10版（ICD - 10）进行诊断评估。
纳入101人，其中29人健康、无痴呆；82名参与者在第二次访视时接受评估，90名在第三次访视时接受评估，但仅有88份评分可用。MMSE的最佳截断值为≥26。MMSE的评分者间信度和重测信度（r = 0.91）较高，与整体量表的相关性也较高。然而，与临床总体印象量表（CGI）和老年抑郁量表（GDS）值相关的平均得分（±标准差）、中位数得分及范围存在相当大的差异。MMSE评分与性别和教育水平无关。
在目前的丹麦版本中，MMSE也被证明是一个可靠的量表。它具有出色的评分者间信度和重测信度。截断值为26被证明比此前常用的24更好。然而，在相同的总体严重程度范围内，MMSE评分范围分布如此分散，以至于一般不应使用MMSE来描述痴呆症的严重程度。
