Watt Heather L, Kharmate G, Kumar Ujendra
Department of Medicine, Royal Victoria Hospital, McGill University, Canada.
Mol Cell Endocrinol. 2008 May 14;286(1-2):251-61. doi: 10.1016/j.mce.2008.01.006. Epub 2008 Jan 20.
The biological effects of the neuropeptide somatostatin (SST) are mediated via a family of five somatostatin receptors (SSTRs) belonging to a family of G-protein-coupled receptors (GPCRs). SSTR regulate the secretion of hormones, growth factors, neurotransmission and cell growth in receptor-specific manner. In addition, SST plays an inhibitory role in several mammary cancer models. These effects are mediated both indirectly through inhibition of hormones and growth factors which promote tumor growth as well as directly via SSTRs present on tumor cells to inhibit mitogenic signaling of growth factor receptor kinases leading to growth arrest and induction of apoptosis. Here, we present an overview on the role of SST and its analogs in breast cancer.
神经肽生长抑素（SST）的生物学效应是通过属于G蛋白偶联受体（GPCR）家族的五个生长抑素受体（SSTR）家族介导的。SSTR以受体特异性方式调节激素分泌、生长因子、神经传递和细胞生长。此外，SST在几种乳腺癌模型中起抑制作用。这些作用既通过抑制促进肿瘤生长的激素和生长因子间接介导，也通过肿瘤细胞上存在的SSTR直接介导，以抑制生长因子受体激酶的促有丝分裂信号传导，导致生长停滞和诱导细胞凋亡。在此，我们概述了SST及其类似物在乳腺癌中的作用。
