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对多药耐药癌细胞系显示出细胞毒性的吲哚和中氮茚乙二酰胺。

Indole- and indolizine-glyoxylamides displaying cytotoxicity against multidrug resistant cancer cell lines.

作者信息

James David A, Koya Keizo, Li Hao, Liang Guiqing, Xia Zhiqiang, Ying Weiwen, Wu Yaming, Sun Lijun

机构信息

Synta Pharmaceuticals, 45 Hartwell Ave, Lexington, MA 02421, USA.

出版信息

Bioorg Med Chem Lett. 2008 Mar 15;18(6):1784-7. doi: 10.1016/j.bmcl.2008.02.029. Epub 2008 Feb 16.

DOI:10.1016/j.bmcl.2008.02.029
PMID:18308566
Abstract

We report herein the SAR studies of a series of indole- and indolizine-glyoxylamides that demonstrate substantial in vitro anti-proliferative activities against cancer cell lines, including multidrug resistance (MDR) phenotypes. The in vitro cytotoxic effects have been demonstrated across a wide array of tumor types of various origins (e.g., breast, colon, uterine).

摘要

我们在此报告了一系列吲哚和中氮茚乙二醛酰胺的构效关系研究，这些研究表明它们对癌细胞系具有显著的体外抗增殖活性，包括多药耐药（MDR）表型。体外细胞毒性作用已在多种不同起源的肿瘤类型（如乳腺癌、结肠癌、子宫癌）中得到证实。

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