Giraudeau Patrick, Akoka Serge
Université de Nantes, Nantes Atlantique Universités, CNRS, Laboratoire d'Analyse Isotopique et Electrochimique de Métabolismes, UMR 6006, Faculté des Sciences, B.P. 92208, Nantes Cedex 03, France.
J Magn Reson. 2008 May;192(1):151-8. doi: 10.1016/j.jmr.2008.02.007. Epub 2008 Feb 14.
Recent ultrafast techniques make it possible to obtain nD NMR spectra in a single scan. However, an important sensitivity decrease is observed when the excitation duration is increased, which is necessary to improve resolution. A detailed, theoretical and experimental study of sensitivity losses in ultrafast experiments is carried out on the example of J-resolved spectroscopy. The importance of molecular diffusion effects during both encoding and acquisition phases is shown by numerical simulations and experimental results. Other possible sources of signal-to-noise decrease are also considered, such as transverse relaxation, homonuclear J-couplings or chemical shift effects.
