αβ T淋巴细胞缺失小鼠，一种用于γδ T淋巴细胞功能研究的模型。
Alpha beta T-lymphocyte depleted mice, a model for gamma delta T-lymphocyte functional studies.
作者信息
Carbone A, Harbeck R, Dallas A, Nemazee D, Finkel T, O'Brien R, Kubo R, Born W
机构信息
Department of Molecular and Cellular Biology, University of California, Berkeley.
出版信息
Immunol Rev. 1991 Apr;120:35-50. doi: 10.1111/j.1600-065x.1991.tb00586.x.
Abstract
Adult mice can be depleted of essentially all mature alpha beta T lymphocytes by chronic treatment with the framework-recognizing, pan-specific anti-TCR alpha beta mAb, H57-597. Similar findings have been reported in rats, gamma delta cell populations remain essentially unaltered in size and reactivity. Suppression of alpha beta T-cell development results in the loss of alloantigen reactivity and of B-cell help, suggesting that gamma delta and alpha beta populations differ in their functional capabilities. Indirect effects of the antibody treatment include quantitative changes in splenic B cells, as well as reduced sizes and weights of experimental animals. alpha beta-suppressed mice and rats may provide model systems for studies on gamma delta cell function in vivo.
摘要
通过用识别框架的泛特异性抗TCRαβ单克隆抗体H57-597进行长期治疗，成年小鼠基本上所有成熟的αβT淋巴细胞都可被清除。在大鼠中也有类似的发现，γδ细胞群体的大小和反应性基本保持不变。αβT细胞发育的抑制导致同种异体抗原反应性和B细胞辅助功能的丧失，这表明γδ和αβ细胞群体在功能能力上存在差异。抗体治疗的间接影响包括脾B细胞的数量变化，以及实验动物的体型和体重减轻。αβ细胞被抑制的小鼠和大鼠可能为体内γδ细胞功能的研究提供模型系统。
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