Skilton Michael R
Human Nutrition Research Centre, Université Claude Bernard, Lyon, France.
Pediatrics. 2008 Mar;121(3):570-4. doi: 10.1542/peds.2007-1801.
Evidence from noninvasive ultrasound studies of the neonatal aorta and fetal and early childhood postmortem studies indicates that impaired fetal growth, in utero exposure to maternal hypercholesterolemia, and diabetic macrosomia may all be important risk factors for vascular changes consistent with the earliest physical signs of atherosclerosis. Although the exact mechanisms that underlie these associations remain unclear, animal models have suggested that the use of antioxidant, lipid-lowering, and other innovative therapies may counteract the impact of these intrauterine risk factors for cardiovascular disease. This review summarizes the current evidence for intrauterine factors that have a direct impact on atherosclerosis and provides potential treatment and prevention strategies.
来自新生儿主动脉的无创超声研究以及胎儿和幼儿期尸检研究的证据表明，胎儿生长受限、子宫内暴露于母体高胆固醇血症以及糖尿病巨大儿可能都是与动脉粥样硬化最早体征一致的血管变化的重要危险因素。尽管这些关联背后的确切机制仍不清楚，但动物模型表明，使用抗氧化剂、降脂药物和其他创新疗法可能会抵消这些子宫内心血管疾病危险因素的影响。本综述总结了目前关于对动脉粥样硬化有直接影响的子宫内因素的证据，并提供了潜在的治疗和预防策略。
