鼠疫耶尔森氏菌1型荚膜的生物合成及超微结构分析
Biogenesis of the fraction 1 capsule and analysis of the ultrastructure of Yersinia pestis.
作者信息
Runco Lisa M, Myrczek Selina, Bliska James B, Thanassi David G
机构信息
Center for Infectious Diseases, Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11794-512, USA.
出版信息
J Bacteriol. 2008 May;190(9):3381-5. doi: 10.1128/JB.01840-07. Epub 2008 Feb 29.
Abstract
Analysis of a Yersinia pestis Delta caf1A mutant demonstrated that the Caf1A usher is required for the assembly and secretion of the fraction 1 capsule. The capsule assembled into thin fibrils and denser aggregates on the bacterial surface. Pilus-like fibers were also detected on the surface of Y. pestis. The capsule occasionally coated these fibers, suggesting how the capsule may cloak surface features to prevent host recognition.
摘要
对鼠疫耶尔森菌caf1A缺失突变体的分析表明，Caf1A外膜蛋白转运体对于1型荚膜的组装和分泌是必需的。该荚膜在细菌表面组装成细纤维和更致密的聚集体。在鼠疫耶尔森菌表面还检测到了菌毛样纤维。荚膜偶尔会覆盖这些纤维，这表明荚膜可能如何掩盖表面特征以防止宿主识别。
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本文引用的文献
1
Characterization of six novel chaperone/usher systems in Yersinia pestis.鼠疫耶尔森菌中六种新型伴侣蛋白/外膜蛋白转运系统的特性分析
Adv Exp Med Biol. 2007;603:97-105. doi: 10.1007/978-0-387-72124-8_8.
2
Effects of Psa and F1 on the adhesive and invasive interactions of Yersinia pestis with human respiratory tract epithelial cells.Psa和F1对鼠疫耶尔森菌与人类呼吸道上皮细胞黏附及侵袭相互作用的影响。
Infect Immun. 2006 Oct;74(10):5636-44. doi: 10.1128/IAI.00612-06.
3
NEW ANTIGENIC COMPONENT OF PASTEURELLA PESTIS FORMED UNDER SPECIFIED CONDITIONS OF pH AND TEMPERATURE.在特定pH和温度条件下形成的鼠疫耶尔森菌新抗原成分
J Bacteriol. 1961 May;81(5):704-14. doi: 10.1128/jb.81.5.704-714.1961.
4
Fiber assembly by the chaperone-usher pathway.通过伴侣-导路途径进行的纤维组装。
Biochim Biophys Acta. 2004 Nov 11;1694(1-3):259-67. doi: 10.1016/j.bbamcr.2004.02.010.
5
A rapid and simple method for inactivating chromosomal genes in Yersinia.一种快速简便的使耶尔森氏菌染色体基因失活的方法。
FEMS Immunol Med Microbiol. 2003 Sep 22;38(2):113-6. doi: 10.1016/S0928-8244(03)00181-0.
6
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Cell. 2003 May 30;113(5):587-96. doi: 10.1016/s0092-8674(03)00351-9.
7
Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation.菌毛亚基的伴侣引发促进了一种拓扑转变，该转变驱动纤维形成。
Cell. 2002 Nov 15;111(4):543-51. doi: 10.1016/s0092-8674(02)01050-4.
8
Donor strand complementation mechanism in the biogenesis of non-pilus systems.非菌毛系统生物合成中的供体链互补机制。
Mol Microbiol. 2002 Aug;45(4):983-95. doi: 10.1046/j.1365-2958.2002.03066.x.
9
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10
Genome sequence of Yersinia pestis, the causative agent of plague.鼠疫病原体——鼠疫耶尔森菌的基因组序列。
Nature. 2001 Oct 4;413(6855):523-7. doi: 10.1038/35097083.
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