Runco Lisa M, Myrczek Selina, Bliska James B, Thanassi David G
Center for Infectious Diseases, Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11794-512, USA.
J Bacteriol. 2008 May;190(9):3381-5. doi: 10.1128/JB.01840-07. Epub 2008 Feb 29.
Analysis of a Yersinia pestis Delta caf1A mutant demonstrated that the Caf1A usher is required for the assembly and secretion of the fraction 1 capsule. The capsule assembled into thin fibrils and denser aggregates on the bacterial surface. Pilus-like fibers were also detected on the surface of Y. pestis. The capsule occasionally coated these fibers, suggesting how the capsule may cloak surface features to prevent host recognition.
对鼠疫耶尔森菌caf1A缺失突变体的分析表明,Caf1A外膜蛋白转运体对于1型荚膜的组装和分泌是必需的。该荚膜在细菌表面组装成细纤维和更致密的聚集体。在鼠疫耶尔森菌表面还检测到了菌毛样纤维。荚膜偶尔会覆盖这些纤维,这表明荚膜可能如何掩盖表面特征以防止宿主识别。