空肠弯曲杆菌CsrA介导氧化应激反应、生物膜形成和宿主细胞侵袭。
Campylobacter jejuni CsrA mediates oxidative stress responses, biofilm formation, and host cell invasion.
作者信息
Fields Joshua A, Thompson Stuart A
机构信息
Department of Biochemistry and Molecular Biology, Medical College of Georgia, 1459 Laney-Walker Blvd., Augusta, GA 30912, USA.
出版信息
J Bacteriol. 2008 May;190(9):3411-6. doi: 10.1128/JB.01928-07. Epub 2008 Feb 29.
Abstract
The putative global posttranscriptional regulator csrA was mutated in Campylobacter jejuni 81-176. The csrA mutant was attenuated in surviving oxidative stress. CsrA also contributed to biofilm formation and adherence to and invasion of INT407 intestinal epithelial cells, suggesting a regulatory role for CsrA in C. jejuni pathogenesis.
摘要
推测的全局转录后调节因子CsrA在空肠弯曲菌81-176中发生了突变。CsrA突变体在抵抗氧化应激方面能力减弱。CsrA还促进了生物膜形成以及对INT407肠上皮细胞的黏附和侵袭，这表明CsrA在空肠弯曲菌致病过程中发挥调节作用。
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