Delaporte Elise, Karki Anand B, Fakhr Mohamed K
Department of Biological Science, The University of Tulsa, Tulsa, OK 74104, USA.
Department of Biological Sciences, Sam Houston State University, Huntsville, TX 77341, USA.
Pathogens. 2024 Sep 28;13(10):842. doi: 10.3390/pathogens13100842.
spp. constitute a group of microaerophilic bacteria that includes strains that are aerotolerant and capable of surviving in aerobic conditions. Recent studies have shown that aerotolerant strains are highly prevalent in meats, animals, and clinical settings. Changes in growth media and other environmental conditions can affect the aerotolerance of strains and must be considered when studying their aerotolerance in vitro. Polymicrobial interactions and biofilms also play a significant role in the ability of to survive oxygen exposure. Continuous subculturing may foster aerotolerance, and studies have demonstrated a positive correlation between aerotolerance and virulence and between aerotolerance and the ability to survive stressful environmental conditions. Various mechanisms and genetic origins for aerotolerance have been proposed; however, most of the potential genes involved in aerotolerance require further investigation, and many candidate genes remain unidentified. Research is also needed to investigate if there are any clinical implications for aerotolerance. Understanding the aerotolerance of remains an important target for further research, and it will be an important step towards identifying potential targets for intervention against this clinically important food-borne pathogen.
某些物种构成了一组微需氧细菌，其中包括耐氧菌株，这些菌株能够在有氧条件下存活。最近的研究表明，耐氧菌株在肉类、动物和临床环境中高度普遍。生长培养基和其他环境条件的变化会影响菌株的耐氧性，在体外研究其耐氧性时必须予以考虑。多微生物相互作用和生物膜在其耐受氧气暴露的能力中也起着重要作用。连续传代培养可能会增强耐氧性，并且研究表明耐氧性与毒力之间以及耐氧性与在应激环境条件下存活的能力之间存在正相关。已经提出了耐氧性的各种机制和遗传起源；然而，大多数与耐氧性相关的潜在基因需要进一步研究，并且许多候选基因仍未被鉴定。还需要进行研究以调查耐氧性是否有任何临床意义。了解其耐氧性仍然是进一步研究的重要目标，这将是朝着确定针对这种临床上重要的食源性病原体的潜在干预目标迈出的重要一步。
