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肠出血性大肠杆菌利用EspA丝状体附着在生菜叶上。

Enterohemorrhagic Escherichia coli exploits EspA filaments for attachment to salad leaves.

作者信息

Shaw Robert K, Berger Cedric N, Feys Bart, Knutton Stuart, Pallen Mark J, Frankel Gad

机构信息

Division of Immunity and Infection, School of Medicine, University of Birmingham, Birmingham, United Kingdom.

出版信息

Appl Environ Microbiol. 2008 May;74(9):2908-14. doi: 10.1128/AEM.02704-07. Epub 2008 Feb 29.

DOI:10.1128/AEM.02704-07
PMID:18310437
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2394865/
Abstract

Enterohemorrhagic Escherichia coli (EHEC) strains are important food-borne pathogens that use a filamentous type III secretion system (fT3SS) for colonization of the gut epithelium. In this study we have shown that EHEC O157 and O26 strains use the fT3SS apparatus for attachment to leaves. Leaf attachment was independent of effector protein translocation.

摘要

肠出血性大肠杆菌（EHEC）菌株是重要的食源性病原体，它们利用丝状III型分泌系统（fT3SS）在肠道上皮定殖。在本研究中，我们已表明EHEC O157和O26菌株利用fT3SS装置附着于叶片。叶片附着独立于效应蛋白易位。

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Vaccination of calves with EspA, a key colonisation factor of Escherichia coli O157:H7, induces antigen-specific humoral responses but does not confer protection against intestinal colonisation.用大肠杆菌O157:H7的关键定植因子EspA对犊牛进行疫苗接种，可诱导抗原特异性体液反应，但不能提供针对肠道定植的保护。
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