Villamin Charles A C, Navarra Sandra V
Section of Rheumatology, Clinical Immunology and Osteoporosis, University of Santo Tomas, Manila, Philippines.
Mod Rheumatol. 2008;18(2):161-4. doi: 10.1007/s10165-008-0029-0. Epub 2008 Mar 4.
The aim of this study was to describe the presenting clinical manifestations and syndromes of Filipino patients on diagnosis of systemic lupus erythematosus (SLE). We performed a retrospective review of medical records of Filipino SLE patients included in the lupus database of the University of Santo Tomas (UST) in Manila, Philippines. All patients fulfilled the American College of Rheumatology criteria for SLE. The following data were recorded: (1) demographic profile, (2) clinical manifestations on SLE diagnosis, and (3) clinical syndromes prior to and during fulfillment of diagnostic criteria for SLE and disease interval from diagnosis of a clinical syndrome to SLE diagnosis. Clinical data of 1,070 patients entered into the UST lupus database as of October 2005 were analyzed. The average age at SLE diagnosis was 28.5 +/- 11.5 (range 5-71) years, with 1,025 female and 45 male subjects. The most common presenting manifestation was arthritis (68%), followed by malar rash (49%), renal involvement (47%), photosensitivity (33%), and oral ulcers (33%). The following clinical syndromes were recorded prior to or during SLE diagnosis: nephrotic syndrome (30%), undifferentiated connective tissue disease (UCTD) (22%), autoimmune hemolytic anemia (AIHA) (6%), and idiopathic thrombocytopenic purpura (ITP) (6%). Among these, AIHA preceded the diagnosis of SLE at the longest interval (20.3 +/- 30.6, range 1-194 months). In this large database of Filipino patients with SLE, the most common presenting manifestation was arthritis, with renal involvement occurring in almost 50%. Among the clinical syndromes, nephrotic syndrome was the most common, whereas AIHA recorded the longest interval preceding SLE diagnosis, at an average of 20.3 months. Our findings are similar to data from other countries and emphasize the broad range of manifestations of SLE. The findings also reinforce the need to establish and maintain SLE databases to enhance awareness, early diagnosis, and more efficient management of the disease.
本研究旨在描述菲律宾系统性红斑狼疮（SLE）患者确诊时的临床表现和综合征。我们对菲律宾马尼拉圣托马斯大学（UST）狼疮数据库中纳入的菲律宾SLE患者的病历进行了回顾性分析。所有患者均符合美国风湿病学会的SLE诊断标准。记录了以下数据：（1）人口统计学资料，（2）SLE诊断时的临床表现，以及（3）达到SLE诊断标准之前及期间的临床综合征，以及从临床综合征诊断到SLE诊断的疾病间隔时间。对截至2005年10月录入UST狼疮数据库的1070例患者的临床资料进行了分析。SLE诊断时的平均年龄为28.5±11.5（范围5 - 71）岁，其中女性1025例，男性45例。最常见的临床表现为关节炎（68%），其次为蝶形红斑（49%）、肾脏受累（47%）、光过敏（33%）和口腔溃疡（33%）。在SLE诊断之前或期间记录到以下临床综合征：肾病综合征（30%）、未分化结缔组织病（UCTD）（22%）、自身免疫性溶血性贫血（AIHA）（6%）和特发性血小板减少性紫癜（ITP）（6%）。其中，AIHA在SLE诊断之前的间隔时间最长（20.3±30.6，范围1 - 194个月）。在这个庞大的菲律宾SLE患者数据库中，最常见的临床表现为关节炎，近50%的患者有肾脏受累。在临床综合征中，肾病综合征最为常见，而AIHA在SLE诊断之前的间隔时间最长，平均为20.3个月。我们的研究结果与其他国家的数据相似，强调了SLE临床表现的广泛多样性。这些结果还强化了建立和维护SLE数据库以提高对该疾病的认识、早期诊断和更有效管理的必要性。
