Schneider T, Coan P, Habs D, Reiser M
Institut für Klinische Radiologie, Klinikum Ludwig-Maximilians-Universität München, München.
Radiologe. 2008 Apr;48(4):345-50. doi: 10.1007/s00117-008-1637-6.
The early and reliable detection of breast cancer is often difficult with conventional mammography, especially within dense breast parenchyma. An alternative approach using x-rays are phase-sensitive imaging techniques, which are able to visualize the borders of tissues with different refraction indices with very high contrast. These phase contrast imaging techniques can generate projection images with much less glandular dose than conventional mammography. Even the acquisition of phase contrast CT data sets with an acceptable exposure dose is possible. As brilliant x-ray beams are required for phase contrast imaging, which up to now were only available at synchrotron facilities, these methods were restricted to only a few laboratories. However, with the advent of newly developed high intensity lasers which are also able to produce such radiation, a widespread and affordable use of this technique seems realistic. The further development of phase contrast imaging is funded by the excellence cluster MAP of the Munich universities.
对于传统乳腺钼靶检查而言，早期且可靠地检测乳腺癌往往很困难，尤其是在乳腺实质致密的情况下。一种使用X射线的替代方法是相敏成像技术，该技术能够以非常高的对比度可视化具有不同折射率的组织边界。这些相衬成像技术可以产生比传统乳腺钼靶检查腺体剂量少得多的投影图像。甚至有可能以可接受的曝光剂量采集相衬CT数据集。由于相衬成像需要高亮度X射线束，而到目前为止只有在同步加速器设施中才能获得，因此这些方法仅限于少数实验室。然而，随着新开发的高强度激光的出现，其也能够产生这种辐射，这项技术的广泛且经济适用的应用似乎是现实可行的。相衬成像的进一步发展由慕尼黑大学卓越集群MAP资助。
