Burns Emily K, Levinson Arnold H
University of Colorado Denver, Aurora, Colorado, USA.
Am J Prev Med. 2008 Mar;34(3):212-5. doi: 10.1016/j.amepre.2007.11.010.
Nicotine replacement therapy (NRT) doubles successful quitting, but more than half of NRT users do not comply with optimal treatment regimens.
From the 2005 Colorado state tobacco survey, quit attempters who utilized NRT (N=366) were analyzed in spring 2007. Descriptive and regression analyses were used to examine reasons for discontinuing NRT, length of time on NRT, and quit intentions.
The reasons for discontinuing NRT were resuming smoking (34%), side effects (17%), NRT not helping with quitting (14%), quitting smoking (10%), and cost (5%). Poverty, age, and non-Latino minority status were associated with reasons for discontinuation other than quitting smoking. Having side effects was associated with a short duration of NRT use and 95% lower odds of intending to quit in the next month.
In the first population-level study examining reasons for discontinuing NRT, general-population smokers who initiate NRT use when attempting to quit are highly likely to discontinue NRT prematurely. Age and culturally-appropriate medication management interventions may increase NRT compliance and improve cessation outcomes.
尼古丁替代疗法（NRT）可使成功戒烟的几率翻倍，但超过一半的NRT使用者未遵循最佳治疗方案。
对2005年科罗拉多州烟草调查中使用NRT的戒烟尝试者（N = 366）于2007年春季进行分析。采用描述性和回归分析来研究停止使用NRT的原因、使用NRT的时长以及戒烟意愿。
停止使用NRT的原因包括重新吸烟（34%）、副作用（17%）、NRT对戒烟无帮助（14%）、已戒烟（10%）和费用（5%）。贫困、年龄和非拉丁裔少数族裔身份与除戒烟外的停药原因相关。出现副作用与NRT使用时间短以及下个月打算戒烟的几率降低95%相关。
在第一项针对停止使用NRT原因的人群水平研究中，尝试戒烟时开始使用NRT的普通人群吸烟者极有可能过早停止使用NRT。年龄和符合文化背景的药物管理干预措施可能会提高NRT的依从性并改善戒烟效果。
