局部应用环丙沙星/地塞米松或单独使用地塞米松对小鼠急性肺炎链球菌性鼻-鼻窦炎的影响。
Effect of topical ciprofloxacin/dexamethasone or dexamethasone alone on acute Streptococcus pneumoniae rhinosinusitis in mice.
作者信息
Sahin-Yilmaz Asli, Baroody Fuad, Markaryan Adam, Thompson Kenneth, Wall G Michael, Naclerio Robert
机构信息
Department of Surgery, Section of Otolaryngology Head and Neck Surgery, The University of Chicago, Chicago, IL 60637, USA.
出版信息
Otolaryngol Head Neck Surg. 2008 Mar;138(3):340-6. doi: 10.1016/j.otohns.2007.11.023.
OBJECTIVE
To test whether intranasal ciprofloxacin/dexamethasone or dexamethasone alone affects the course of acute bacterial rhinosinusitis in mice.
STUDY DESIGN
We performed a randomized, double-blind, parallel, placebo-controlled study in mice.
SUBJECTS AND METHODS
Three groups of 10 C57Bl/6 mice were infected with Streptococcus pneumoniae, and then 1 day later randomized to treatment with placebo, ciprofloxacin plus dexamethasone, or dexamethasone. The mice were killed 3 or 10 days after treatment was begun.
RESULTS
The placebo-treated mice became infected and developed an inflammatory cell infiltration in their sinuses. None of the treatments significantly affected the course of the illness.
CONCLUSION
The lack of topical, intranasal efficacy of ciprofloxacin and dexamethasone could be attributed to subpotent dosage, rapid nasal clearance, or inability of the drops to reach the site of infection. Treatment with dexamethasone neither improved nor worsened the bacterial infection.
目的
测试鼻内给予环丙沙星/地塞米松或单独给予地塞米松是否会影响小鼠急性细菌性鼻窦炎的病程。
研究设计
我们在小鼠中进行了一项随机、双盲、平行、安慰剂对照研究。
对象与方法
将三组10只C57Bl/6小鼠感染肺炎链球菌，1天后随机分为接受安慰剂、环丙沙星加地塞米松或地塞米松治疗。治疗开始后3天或10天处死小鼠。
结果
接受安慰剂治疗的小鼠被感染，鼻窦出现炎性细胞浸润。所有治疗均未显著影响疾病进程。
结论
环丙沙星和地塞米松缺乏鼻内局部疗效可能归因于剂量不足、鼻腔快速清除或滴剂无法到达感染部位。地塞米松治疗既未改善也未加重细菌感染。
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