鼻窦黑色素瘤：61例临床病理分析
Sinonasal melanoma: a clinicopathologic review of 61 cases.
作者信息
Dauer Eileen H, Lewis Jean E, Rohlinger Audrey L, Weaver Amy L, Olsen Kerry D
机构信息
Department of Otorhinolaryngology, Mayo Clinic, Rochester, MN 55905, USA.
出版信息
Otolaryngol Head Neck Surg. 2008 Mar;138(3):347-52. doi: 10.1016/j.otohns.2007.12.013.
OBJECTIVE
To review the Mayo Clinic experience with sinonasal melanoma.
STUDY DESIGN
Retrospective review (case series).
SUBJECTS AND METHODS
We identified 61 patients who had melanoma arising from the nasal cavity, paranasal sinuses, or both. All were treated at our institution from 1955 through 2003. Clinical and pathologic data were summarized, and survival curves were generated.
RESULTS
The most common symptoms at presentation were epistaxis and nasal congestion. The most common treatment was excision only (48%). The cancer-specific survival rate (ie, rate of death due to disease) was 48.9% and 22.1% at 3 and 5 years, respectively. Median time between diagnosis and death due to disease was 19 months.
CONCLUSION
Sinonasal melanoma is a rare but devastating disease. Wide local excision is the treatment of choice, and some patients may benefit from postoperative radiotherapy. Local recurrence and distant metastasis are common. Improved survival depends on better systemic therapies.
目的
回顾梅奥诊所治疗鼻窦黑色素瘤的经验。
研究设计
回顾性研究（病例系列）。
研究对象与方法
我们确定了61例鼻腔、鼻窦或两者均发生黑色素瘤的患者。所有患者于1955年至2003年在我院接受治疗。总结临床和病理数据，并绘制生存曲线。
结果
就诊时最常见的症状是鼻出血和鼻塞。最常见的治疗方法是单纯切除（48%）。3年和5年的癌症特异性生存率（即因疾病导致的死亡率）分别为48.9%和22.1%。从诊断到因疾病死亡的中位时间为19个月。
结论
鼻窦黑色素瘤是一种罕见但极具破坏性的疾病。广泛局部切除是首选治疗方法，部分患者可能从术后放疗中获益。局部复发和远处转移很常见。提高生存率依赖于更好的全身治疗。
Zotero 插件