Fukuta Hidekatsu, Little William C
Nagoya City University, Nagoya, Japan.
Heart Fail Clin. 2008 Jan;4(1):1-11. doi: 10.1016/j.hfc.2007.10.004.
Heart failure is defined as the pathologic state in which the heart is unable to pump blood at a rate required by the metabolizing tissues or can do so only with an elevated filling pressure. Heart failure in adults most frequently results from the inability of the left ventricle to fill (diastolic performance) or eject (systolic performance) blood. The severity of heart failure and its prognosis are more closely related to the degree of diastolic filling abnormalities than the ejection fraction, which underscores the importance of understanding the mechanisms of diastolic abnormalities in heart failure.
心力衰竭被定义为一种病理状态,即心脏无法以代谢组织所需的速率泵血,或者只能在升高的充盈压下才能泵血。成人心力衰竭最常见的原因是左心室无法充盈(舒张功能)或射血(收缩功能)。心力衰竭的严重程度及其预后与舒张期充盈异常的程度比与射血分数的关系更为密切,这突出了理解心力衰竭中舒张期异常机制的重要性。