Fortier Lisa A, Smith Roger K W
Department of Clinical Sciences, VMC C3-181, Cornell University, Ithaca, NY 14853, USA.
Vet Clin North Am Equine Pract. 2008 Apr;24(1):191-201. doi: 10.1016/j.cveq.2007.11.002.
After tendon injury, the scar tissue that replaces the damaged tendon results in a substantial risk for reinjury. The goal of regenerative therapies is to restore normal structural architecture and biomechanical function to an injured tissue. Successful restoration processes for any tissue are thought to recapitulate those of development, in which there are spatial and temporal interactions between scaffold, growth factors, and cell populations.
肌腱损伤后,替代受损肌腱的瘢痕组织会带来再次受伤的重大风险。再生疗法的目标是使受损组织恢复正常的结构架构和生物力学功能。任何组织的成功修复过程都被认为是重现发育过程,在发育过程中,支架、生长因子和细胞群体之间存在时空相互作用。