Trifirò Gianluca, Savica Rodolfo, Morgante Letterio, Vanacore Nicola, Tari Michele, Moretti Salvatore, Galdo Mariella, Spina Edoardo, Caputi Achille P, Arcoraci Vincenzo
Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Via Consolare Valeria-Gazzi, 98125 Messina, Italy.
Parkinsonism Relat Disord. 2008;14(5):420-5. doi: 10.1016/j.parkreldis.2007.10.010. Epub 2008 Mar 3.
Aim of this study was to evaluate prevalence of use and prescribing pattern of Anti-Parkinson Drugs (APDs) in general practice of Southern Italy. Among 120,000 individuals registered in the lists of 93 general practitioners of Southern Italy, we estimated one-year prevalence and incidence of APD use in the years 2003-2005. Overall, prevalence of APD use remained stable over the years and it strongly increased in subjects over 70 years of age. L-Dopa with a dopa decarboxylase inhibitor was the most frequently prescribed APD, although the use of both ergot and non-ergot derivative DAs has increased, particularly, in the elderly. A high proportion of APD users (15-20%) received only one prescription during the study period.
本研究的目的是评估意大利南部全科医疗中抗帕金森病药物(APD)的使用 prevalence 和处方模式。在意大利南部93名全科医生名单上登记的120,000人中,我们估计了2003 - 2005年期间APD使用的一年 prevalence 和发病率。总体而言,这些年APD的使用 prevalence 保持稳定,且在70岁以上人群中显著增加。左旋多巴与多巴脱羧酶抑制剂是最常处方的APD,尽管麦角类和非麦角类衍生物多巴胺能激动剂(DA)的使用都有所增加,尤其是在老年人中。在研究期间,很大一部分APD使用者(15 - 20%)仅收到过一张处方。